LHX3 and CCDC146

Data Source:
BioGRID (two hybrid)

		LHX3	CCDC146
Description		LIM homeobox 3	coiled-coil domain containing 146
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Cytoplasm Centriole Cytoskeleton
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Metal Ion Binding	Protein Binding
	Biological Process	Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 28552196 20189936) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)	Body mass index ( 28892062) Response to amphetamines ( 22952603)
Interacting Genes		78 interacting genes: ABI2 ACTN3 AIF1L ANKRD45 ANP32A ATP6V1G1 BYSL C2CD6 CCDC146 CCDC6 CDC23 CDK3 CITED2 CKS1B CLCNKA CPNE7 CSNK2A1 CWF19L2 ENKD1 FAIM FAM124B FAM221A FIGLA GAS2L2 GAS8 GCM2 GUCD1 HOXC5 HOXC8 IFT172 INCA1 INSC INTS4 IQUB ISL1 ISL2 KANK2 KLHL38 KRT3 LDB1 LHX1 LMX1A MAPK9 NFKBID NRDE2 NRF1 NUDT22 OCRL PARP11 PARVG PNMA5 PRKAB2 PSMB1 PSORS1C2 QRICH1 RCOR3 RHBDF1 RLIM RUNX1T1 SAT1 SCNM1 SH2D1A SNRNP25 TAF1 TCEANC TEX14 TLE5 TSEN54 TSSK3 UBTFL1 USP2 VEZF1 YY1 ZNF354C ZNF417 ZNF574 ZNF587 ZNF76	71 interacting genes: AKAP9 BLOC1S2 CBY2 CCDC136 CCDC197 CCNDBP1 CDR2 CDR2L CENPH CEP170P1 CEP44 DTNBP1 FSD2 GAS8 GMNN GOLGA2 GOLGA6L9 GPRASP2 GRAMD4 HSF2BP INSYN1 KIFC3 KRT16 KRT18 KRT19 KRT24 KRT26 KRT27 KRT31 KRT34 KRT38 KRT40 KRT86 LHX3 MAGEA11 MAGEA6 MCC MED4 MIPOL1 MRFAP1 MTUS2 N4BP3 NAP1L2 NECAB2 NINL NUP62 PDE4DIP PLEKHF2 PNMA1 PPP2R3C PROSER3 PSMC6 RINT1 RNF40 RPGRIP1 SH3BP1 SYCE1L TEPSIN TFIP11 THOC7 TNR TPM3 TRAF1 TRIM23 TRIM54 TRIML2 TSC22D4 TXLNA USHBP1 VPS28 VPS52
Entrez ID		8022	57639
HPRD ID		02783	11150
Ensembl ID		ENSG00000107187	ENSG00000135205
Uniprot IDs		F1T0D5 F1T0D9 Q9UBR4	Q8IYE0 Q96MS1
PDB IDs
Enriched GO Terms of Interacting Partners?
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