LHX3 and TEX14

Data Source:
BioGRID (two hybrid)

		LHX3	TEX14
Description		LIM homeobox 3	testis expressed 14, intercellular bridge forming factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Kinetochore Condensed Chromosome Kinetochore Cytoplasm Midbody Intercellular Bridge Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Metal Ion Binding	Protein Kinase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Specification Medial Motor Column Neuron Differentiation Spinal Cord Association Neuron Differentiation Pituitary Gland Development Neuron Differentiation Lung Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development	Protein Phosphorylation Mitotic Spindle Assembly Checkpoint Male Meiotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Protein Binding Negative Regulation Of Cytokinesis Intercellular Bridge Organization Cell Division Mitotic Sister Chromatid Separation Cellular Response To Leukemia Inhibitory Factor
Pathways		Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Atrial fibrillation ( 30061737) Crohn's disease ( 28067908) Free thyroxine concentration ( 25743335) Height ( 28552196 20189936) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Thyroid hormone levels ( 23408906) Ulcerative colitis ( 28067908)	Chronotype ( 30696823) Cognitive function ( 25644384) Estimated glomerular filtration rate ( 31152163) Iron status biomarkers (ferritin levels) ( 25352340) Neutrophil count ( 32888494) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Testicular germ cell tumor ( 25877299 28604728 28604732 23666239 23666240) Type 2 diabetes ( 30054458) White blood cell count ( 32888494)
Interacting Genes		78 interacting genes: ABI2 ACTN3 AIF1L ANKRD45 ANP32A ATP6V1G1 BYSL C2CD6 CCDC146 CCDC6 CDC23 CDK3 CITED2 CKS1B CLCNKA CPNE7 CSNK2A1 CWF19L2 ENKD1 FAIM FAM124B FAM221A FIGLA GAS2L2 GAS8 GCM2 GUCD1 HOXC5 HOXC8 IFT172 INCA1 INSC INTS4 IQUB ISL1 ISL2 KANK2 KLHL38 KRT3 LDB1 LHX1 LMX1A MAPK9 NFKBID NRDE2 NRF1 NUDT22 OCRL PARP11 PARVG PNMA5 PRKAB2 PSMB1 PSORS1C2 QRICH1 RCOR3 RHBDF1 RLIM RUNX1T1 SAT1 SCNM1 SH2D1A SNRNP25 TAF1 TCEANC TEX14 TLE5 TSEN54 TSSK3 UBTFL1 USP2 VEZF1 YY1 ZNF354C ZNF417 ZNF574 ZNF587 ZNF76	5 interacting genes: CEP55 DDIT4L LHX3 LMO4 MEOX2
Entrez ID		8022	56155
HPRD ID		02783	12046
Ensembl ID		ENSG00000107187	ENSG00000121101
Uniprot IDs		F1T0D5 F1T0D9 Q9UBR4	Q8IWB6
PDB IDs			3WUT 3WUU
Enriched GO Terms of Interacting Partners?
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