EME2 and MUS81

Data Source:
BioGRID (pull down)

		EME2	MUS81
Description		essential meiotic structure-specific endonuclease subunit 2	MUS81 structure-specific endonuclease subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Holliday Junction Resolvase Complex	Nucleus Nucleoplasm Nucleolus Holliday Junction Resolvase Complex
	Molecular Function	DNA Binding Endonuclease Activity Protein Binding	DNA Binding Protein Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Replication Fork Processing Intra-S DNA Damage Checkpoint Nucleic Acid Phosphodiester Bond Hydrolysis	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Break-induced Replication DNA Catabolic Process, Endonucleolytic DNA Repair Intra-S DNA Damage Checkpoint Osteoblast Proliferation Interstrand Cross-link Repair Response To Intra-S DNA Damage Checkpoint Signaling
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Breast cancer ( 23535729)
Interacting Genes		4 interacting genes: FAAP24 FANCM MEOX2 MUS81	10 interacting genes: CHEK2 CSNK2A1 DDB1 EME1 EME2 RECQL5 SLX1A SLX4 SUMO2 UHRF1
Entrez ID		197342	80198
HPRD ID		16859	09419
Ensembl ID		ENSG00000197774	ENSG00000172732
Uniprot IDs		A4GXA9	Q53ES5 Q96NY9
PDB IDs			2MC3 2ZIX 4P0P 4P0Q 4P0R 4P0S
Enriched GO Terms of Interacting Partners?
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