FRAS1 and KLHL2

Data Source:
BioGRID (biochemical)

		FRAS1	KLHL2
Description		Fraser extracellular matrix complex subunit 1	kelch like family member 2
Image		No pdb structure
GO Annotations	Cellular Component	Basement Membrane Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Extracellular Matrix Structural Constituent Metal Ion Binding	Actin Binding Protein Binding Identical Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Metanephros Morphogenesis Cell Communication Protein Transport Embryonic Limb Morphogenesis Skin Development Roof Of Mouth Development	Protein Ubiquitination Post-translational Protein Modification
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Fraser syndrome
GWAS		Blond vs. brown/black hair color ( 30531825) Hair morphology ( 19896111) Hair shape ( 29220522) Hemoglobin ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lung function (FEV1/FVC) ( 30804560) Night sleep phenotypes ( 27126917) QT interval ( 29213071) Response to carboplatin in ovarian cancer (MTT IC50) ( 27047539) Retinal detachment or retinal break ( 31816047) Uric acid levels ( 23703922)	Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes			31 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID		80144	11275
HPRD ID		06382	09311
Ensembl ID		ENSG00000138759	ENSG00000109466
Uniprot IDs		Q86XX4	B4DFZ5 E9PEX9 O95198
PDB IDs			2XN4 4CHB
Enriched GO Terms of Interacting Partners?
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