TRIM46 and RNF125

Data Source:
BioGRID (two hybrid)

		TRIM46	RNF125
Description		tripartite motif containing 46	ring finger protein 125
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Axon Initial Segment Main Axon Axon Cytoplasm Proximal Neuron Projection	Golgi Membrane VCP-NPL4-UFD1 AAA ATPase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Zinc Ion Binding	P53 Binding Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Microtubule Bundle Formation Neuron Migration Axonogenesis Negative Regulation Of Axon Extension Anterograde Synaptic Vesicle Transport Protein Localization To Axon Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Cellular Protein Localization	Protein Polyubiquitination Adaptive Immune Response Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Cellular Response To Leukemia Inhibitory Factor
Pathways		Interferon gamma signaling	Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Microalbuminuria ( 31511532) Serum uric acid levels ( 30993211) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31985003 31578528 23263486) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		20 interacting genes: AK5 APP BRCA1 CBLC MDM4 MTNR1B OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2D2 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32	26 interacting genes: BHLHA9 CHFR EFHC1 FNDC11 MYOZ3 PCGF1 PML PNMA6A SPAG8 TP53 TRIM14 TRIM46 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2L6 UBE2N UBE2U UBE2W USP2 ZNF414
Entrez ID		80128	54941
HPRD ID		15563	11500
Ensembl ID		ENSG00000163462	ENSG00000101695
Uniprot IDs		A0A087WUH1 B7Z4F9 F5GYK0 Q7Z4K8	Q96EQ8
PDB IDs			5DKA
Enriched GO Terms of Interacting Partners?
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