RNF125 and TRIM46

Data Source:
BioGRID (two hybrid)

		RNF125	TRIM46
Description		ring finger protein 125	tripartite motif containing 46
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane VCP-NPL4-UFD1 AAA ATPase Complex Intracellular Membrane-bounded Organelle	Cytoskeleton Axon Initial Segment Main Axon Axon Cytoplasm Proximal Neuron Projection
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity	Zinc Ion Binding
	Biological Process	Protein Polyubiquitination Adaptive Immune Response Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Microtubule Bundle Formation Neuron Migration Axonogenesis Negative Regulation Of Axon Extension Anterograde Synaptic Vesicle Transport Protein Localization To Axon Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Cellular Protein Localization
Pathways		Negative regulators of DDX58/IFIH1 signaling	Interferon gamma signaling
Drugs
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Microalbuminuria ( 31511532) Serum uric acid levels ( 30993211) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31985003 31578528 23263486) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		26 interacting genes: BHLHA9 CHFR EFHC1 FNDC11 MYOZ3 PCGF1 PML PNMA6A SPAG8 TP53 TRIM14 TRIM46 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2L6 UBE2N UBE2U UBE2W USP2 ZNF414	20 interacting genes: AK5 APP BRCA1 CBLC MDM4 MTNR1B OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2D2 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32
Entrez ID		54941	80128
HPRD ID		11500	15563
Ensembl ID		ENSG00000101695	ENSG00000163462
Uniprot IDs		Q96EQ8	A0A087WUH1 B7Z4F9 F5GYK0 Q7Z4K8
PDB IDs		5DKA
Enriched GO Terms of Interacting Partners?
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