RNF125 and UBE2U

Data Source:
BioGRID (two hybrid)

		RNF125	UBE2U
Description		ring finger protein 125	ubiquitin conjugating enzyme E2 U
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GO Annotations	Cellular Component	Golgi Membrane VCP-NPL4-UFD1 AAA ATPase Complex Intracellular Membrane-bounded Organelle	HULC Complex
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Adaptive Immune Response Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Negative regulators of DDX58/IFIH1 signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Severe bacterial meningitis ( 31092817)
Interacting Genes		26 interacting genes: BHLHA9 CHFR EFHC1 FNDC11 MYOZ3 PCGF1 PML PNMA6A SPAG8 TP53 TRIM14 TRIM46 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2L6 UBE2N UBE2U UBE2W USP2 ZNF414	68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		54941	148581
HPRD ID		11500	14599
Ensembl ID		ENSG00000101695	ENSG00000177414
Uniprot IDs		Q96EQ8	A0A140VJY9 Q5VVX9
PDB IDs		5DKA	1YRV
Enriched GO Terms of Interacting Partners?
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