RNF125 and CHFR

Data Source:
BioGRID (two hybrid)

		RNF125	CHFR
Description		ring finger protein 125	checkpoint with forkhead and ring finger domains
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GO Annotations	Cellular Component	Golgi Membrane VCP-NPL4-UFD1 AAA ATPase Complex Intracellular Membrane-bounded Organelle	Nucleus PML Body
	Molecular Function	P53 Binding Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Adaptive Immune Response Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Meiotic Spindle Checkpoint Cell Division
Pathways		Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS			Cognitive function ( 24684796) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373)
Interacting Genes		26 interacting genes: BHLHA9 CHFR EFHC1 FNDC11 MYOZ3 PCGF1 PML PNMA6A SPAG8 TP53 TRIM14 TRIM46 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E2 UBE2K UBE2L3 UBE2L6 UBE2N UBE2U UBE2W USP2 ZNF414	30 interacting genes: AURKA BRD4 CBLC EEF1G GABBR1 GRB10 GRB14 HDAC1 HDAC2 ITGAE PML RNF125 RNF7 SIRT1 SMARCA4 SMARCB1 SMARCD1 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2L1 UBE2N UBE2W WDR47
Entrez ID		54941	55743
HPRD ID		11500	05552
Ensembl ID		ENSG00000101695	ENSG00000072609
Uniprot IDs		Q96EQ8	Q96EP1
PDB IDs		5DKA	1LGP 1LGQ 2XOC 2XOY 2XOZ 2XP0
Enriched GO Terms of Interacting Partners?
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