TRIM46 and AK5

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIM46	AK5
Description		tripartite motif containing 46	adenylate kinase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Axon Initial Segment Main Axon Axon Cytoplasm Proximal Neuron Projection	Cytoplasm Cytosol Centriolar Satellite
	Molecular Function	Zinc Ion Binding	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity ATP Binding
	Biological Process	Microtubule Bundle Formation Neuron Migration Axonogenesis Negative Regulation Of Axon Extension Anterograde Synaptic Vesicle Transport Protein Localization To Axon Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Cellular Protein Localization	Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process DADP Biosynthetic Process Nucleoside Triphosphate Biosynthetic Process Pyrimidine Ribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion ATP Metabolic Process Nucleoside Monophosphate Phosphorylation
Pathways		Interferon gamma signaling	Interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Microalbuminuria ( 31511532) Serum uric acid levels ( 30993211) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31985003 31578528 23263486) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)	Body mass index ( 25673413) Chronotype ( 26955885 30696823 27494321) Eosinophil percentage of white cells ( 27863252) Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Immature fraction of reticulocytes ( 32888494) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean reticulocyte volume ( 32888494) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 26835600 27494321) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes (age of onset) ( 28060188) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		20 interacting genes: AK5 APP BRCA1 CBLC MDM4 MTNR1B OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2D2 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32	7 interacting genes: C7orf26 CPNE6 NUCKS1 RNF114 STRN4 TRIM46 UGDH
Entrez ID		80128	26289
HPRD ID		15563	10472
Ensembl ID		ENSG00000163462	ENSG00000154027
Uniprot IDs		A0A087WUH1 B7Z4F9 F5GYK0 Q7Z4K8	Q9Y6K8
PDB IDs			2BWJ
Enriched GO Terms of Interacting Partners?
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