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ZNF408 and UPF2
Data Source:
HPRD
(two hybrid)
ZNF408
UPF2
Description
zinc finger protein 408
UPF2 regulator of nonsense mediated mRNA decay
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleus
Cytoplasm
Cytosol
Polysome
Exon-exon Junction Complex
Cytoplasmic Ribonucleoprotein Granule
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Identical Protein Binding
Metal Ion Binding
RNA Binding
Protein Binding
Telomeric DNA Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Liver Development
MRNA Export From Nucleus
Animal Organ Regeneration
Pathways
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Femoral neck bone mineral density (
29499414
)
Schizophrenia (
29483656
)
Diverticular disease (
30177863
)
Interacting Genes
83 interacting genes:
AEBP2
AEN
APOBEC3C
ATRN
BAHD1
CALCOCO2
CCDC136
CEP70
CHAF1A
CRELD1
CYSRT1
DDX56
DVL3
EXOSC2
FBLN2
FHL2
FHL5
FSD2
GIPC1
GPATCH2L
HNRNPK
HOXA5
HOXB9
ID3
KCTD9
KHDRBS3
KRT40
KRTAP1-1
KRTAP10-7
KRTAP10-8
KRTAP12-2
KRTAP12-3
KRTAP4-12
KRTAP5-9
LDOC1
LSM2
LZTS2
MDFI
MID2
MIF
MRRF
MTUS2
NBPF19
NOTCH2NLA
PDE4DIP
PDLIM4
PICK1
PNMA2
PRAME
PRNP
PRPF31
PSTPIP1
RALY
RALYL
RBM10
RBMY1F
RBMY1J
SAP30BP
SPRED1
SSX2IP
THAP1
TLE5
TOP3B
TRIM23
TRIM41
UBE2I
UPF2
USP20
ZBTB26
ZBTB48
ZBTB8A
ZBTB9
ZC4H2
ZNF212
ZNF317
ZNF330
ZNF331
ZNF473
ZNF526
ZNF764
ZNF792
ZNF837
ZRANB1
76 interacting genes:
ABCF2
AGPAT1
AKTIP
ART4
ATP1B3
BLM
CALR
CENPU
CIZ1
COMTD1
CYBA
DCP1B
DCP2
DPF2
E4F1
EIF1
EIF4A1
EIF4G1
ENO1
EXOSC1
EXOSC10
EXOSC4
EXOSC6
EXOSC8
GADD45GIP1
HBZ
HMGA1
HS3ST3A1
HSF2BP
ITGB1
KRT18
LDHA
LSM1
MAP1A
MAP1LC3B
MIF
MRPL40
MTERF3
MTREX
MYB
NDUFA7
NOB1
NOMO1
NOP53
PHB2
PITX1
PUF60
RNPS1
RPL13
RPL5
RPL8
RPS15
RPS25
RPS6
RPS7
RRP7A
RSRC2
SERBP1
SERF2
SMG1
SUMO3
TK1
TNNI2
TOP3B
TUBB2A
TYMS
UPF1
UPF3B
WNK1
XRN1
XRN2
ZBTB48
ZFP36
ZGPAT
ZNF408
ZNF44
Entrez ID
79797
26019
HPRD ID
18338
10405
Ensembl ID
ENSG00000175213
ENSG00000151461
Uniprot IDs
B4DXY4
Q9H9D4
Q9HAU5
PDB IDs
1UW4
2WJV
4CEK
4CEM
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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