PARP8 and HTR6

Data Source:
BioGRID (two hybrid)

		PARP8	HTR6
Description		poly(ADP-ribose) polymerase family member 8	5-hydroxytryptamine receptor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Protein ADP-ribosylation Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Nicotinamide salvaging Maturation of nucleoprotein Maturation of nucleoprotein	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Callous-unemotional behaviour ( 23874384) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Childhood ear infection ( 27182965) General risk tolerance (MTAG) ( 30643258) HOMA-B (corrected for HOMA-IR) ( 30369944) Myopia (pathological) ( 22685421) Type 2 diabetes ( 32499647 30718926) Verbal declarative memory ( 25648963)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		1 interacting genes: HTR6	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		79668	3362
HPRD ID		07960	03066
Ensembl ID		ENSG00000151883	ENSG00000158748
Uniprot IDs		B2RB27 E9PFI7 Q8N3A8	P50406
PDB IDs
Enriched GO Terms of Interacting Partners?
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