CDC73 and WWC1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDC73	WWC1
Description		cell division cycle 73	WW and C2 domain containing 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Nucleus Cytoplasm Cytosol Ruffle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding	Transcription Coactivator Activity Protein Binding Kinase Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Population Proliferation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Beta-catenin-TCF Complex Assembly Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Of Notch Receptor Target Cell Migration Establishment Of Cell Polarity Regulation Of Intracellular Transport Hippo Signaling Regulation Of Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of MAPK Cascade Negative Regulation Of Organ Growth
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Signaling by Hippo NOTCH3 Intracellular Domain Regulates Transcription
Drugs
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Chronotype ( 30696823) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)	Adult body size ( 32376654) Cerebellum cortex volume ( 31530798) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Epithelial ovarian cancer ( 31469419) Mental health study participation (provided email address) ( 31263887) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Periodontal microbiota ( 22699663) Regular attendance at a religious group ( 29970889) Type 2 diabetes nephropathy including microalbuminuria ( 30566433)
Interacting Genes		35 interacting genes: ALAS1 ANXA6 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 VPS37B WWC1	15 interacting genes: AIFM1 CDC5L CDC73 DDN FAM219A FEZ1 FEZ2 H3C1 KIAA0513 LRIF1 MAPK6 PRKCZ TNIK WWC2 WWC3
Entrez ID		79577	23286
HPRD ID		09581	10033
Ensembl ID		ENSG00000134371	ENSG00000113645
Uniprot IDs		Q6P1J9	Q8IX03
PDB IDs		5YDE 5YDF 6TED	2Z0U 6FB4 6FD0 6FJC 6FJD
Enriched GO Terms of Interacting Partners?
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