CDC73 and PITHD1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDC73	PITHD1
Description		cell division cycle 73	PITH domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Nucleus Cytoplasm Sperm Cytoplasmic Droplet
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Population Proliferation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Beta-catenin-TCF Complex Assembly Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Spermatid Development Penetration Of Zona Pellucida Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process Penetration Of Cumulus Oophorus
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Chronotype ( 30696823) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)	High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		35 interacting genes: ALAS1 ANXA6 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 VPS37B WWC1	2 interacting genes: CDC73 SUMO4
Entrez ID		79577	57095
HPRD ID		09581	13717
Ensembl ID		ENSG00000134371	ENSG00000057757
Uniprot IDs		Q6P1J9	B4DKP7 Q9GZP4
PDB IDs		5YDE 5YDF 6TED
Enriched GO Terms of Interacting Partners?
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