CDC73 and FAF1

Data Source:
BioGRID (two hybrid)

		CDC73	FAF1
Description		cell division cycle 73	Fas associated factor 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Nucleus Nuclear Envelope Nucleoplasm Cytosol CD95 Death-inducing Signaling Complex VCP-NPL4-UFD1 AAA ATPase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Population Proliferation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Beta-catenin-TCF Complex Assembly Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Catabolic Process
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Chronotype ( 30696823) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)	Atrial fibrillation ( 29290336) Blood urea nitrogen levels ( 31152163) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Depression and alcohol dependence ( 22064162) FEV1 ( 30804560) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Multisite chronic pain ( 31194737) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Postprandial triglyceride response ( 32603185) Pulse pressure ( 27841878 30578418) QRS duration ( 30679814 21076409) Renal cell carcinoma ( 28598434) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Type 2 diabetes ( 24509480 30297969 26818947 32499647 30718926 28869590) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		35 interacting genes: ALAS1 ANXA6 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 VPS37B WWC1	46 interacting genes: AKT1 ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CREBBP CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 HSPA1B IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 PRKN RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 SPOP SUMO1 TAF1D TK1 TNNT1 TSC22D1 UBC UBE2I UROD XIAP YTHDF3
Entrez ID		79577	11124
HPRD ID		09581	05124
Ensembl ID		ENSG00000134371	ENSG00000185104
Uniprot IDs		Q6P1J9	Q9UNN5
PDB IDs		5YDE 5YDF 6TED	1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?
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