SELENOS and SAA1

Data Source:
HPRD (in vitro, two hybrid)

		SELENOS	SAA1
Description		selenoprotein S	serum amyloid A1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex	Extracellular Region Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Protein Binding Antioxidant Activity Enzyme Binding Signaling Receptor Activity ATPase Binding Ubiquitin-specific Protease Binding	G Protein-coupled Receptor Binding Heparin Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis ER Overload Response Response To Glucose Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process	Activation Of MAPK Activity Positive Regulation Of Cytokine Production Receptor-mediated Endocytosis Acute-phase Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Production Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation
Drugs
Diseases
GWAS			Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576 29875488 28240269) Rosacea symptom severity ( 29771307)
Interacting Genes		9 interacting genes: APOA5 DERL1 GTF2IRD1 KLHDC2 KPNB1 MFHAS1 SAA1 SRPK2 VCP	9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R LAMA1 SELENOS VKORC1
Entrez ID		55829	6288
HPRD ID		12133	00097
Ensembl ID		ENSG00000131871	ENSG00000173432
Uniprot IDs		Q6GYA4 Q9BQE4	P0DJI8
PDB IDs		2Q2F 5KIU 5KIY 6DO4	4IP8 4IP9 6MST
Enriched GO Terms of Interacting Partners?
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