CFTR and SLC4A8

Data Source:
HPRD (in vivo)

		CFTR	SLC4A8
Description		CF transmembrane conductance regulator	solute carrier family 4 member 8
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Golgi-associated Vesicle Membrane Clathrin-coated Vesicle Membrane Early Endosome Membrane Protein-containing Complex Chloride Channel Complex Recycling Endosome Recycling Endosome Membrane	Plasma Membrane Synaptic Vesicle Membrane Integral Component Of Membrane Dendrite Asymmetric Synapse Symmetric Synapse Neuronal Cell Body Membrane Presynaptic Membrane Neuron Projection Terminal Bouton Axon Terminus Glial Cell Projection Hippocampal Mossy Fiber Presynapse Glutamatergic Synapse
	Molecular Function	Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Isomerase Activity ATPase Activity Chloride Channel Regulator Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding ATPase-coupled Transmembrane Transporter Activity Chaperone Binding Sec61 Translocon Complex Binding	Inorganic Anion Exchanger Activity Sodium:bicarbonate Symporter Activity Sodium Ion Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Anion:anion Antiporter Activity Transmembrane Transporter Activity
	Biological Process	Cholesterol Biosynthetic Process Vesicle Docking Involved In Exocytosis Bicarbonate Transport Protein Deubiquitination Cholesterol Transport Response To Endoplasmic Reticulum Stress Transepithelial Water Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Sperm Capacitation Multicellular Organismal Water Homeostasis Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Membrane Organization Cellular Response To CAMP Positive Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity Cellular Response To Forskolin	Bicarbonate Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Ion Homeostasis Modulation Of Chemical Synaptic Transmission Regulation Of Intracellular PH Transmembrane Transport Transport Across Blood-brain Barrier Chloride Transmembrane Transport Positive Regulation Of Synaptic Vesicle Exocytosis
Pathways		ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Bicarbonate transporters
Drugs		ATP Bumetanide Glyburide Ibuprofen Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor Tezacaftor Elexacaftor
Diseases		Cystic fibrosis (CF) Hereditary pancreatitis; Hereditary chronic pancreatitis Congenital bilateral absence of vas deferens
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Glaucoma ( 30054594) Gout ( 22179738) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alzheimer's disease (cognitive decline) ( 23535033) Fruit consumption ( 32066663) Problematic alcohol use ( 32451486) Response to antidepressants and depression ( 27622933) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		29 interacting genes: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 MARCHF2 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STUB1 STX1A UBE2I	3 interacting genes: CA2 CFTR SLC9A3R1
Entrez ID		1080	9498
HPRD ID		03883	05430
Ensembl ID		ENSG00000001626	ENSG00000050438
Uniprot IDs		A0A024R730 P13569	Q2Y0W8
PDB IDs		1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW 4WZ6 5D2D 5D3E 5D3F 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFF 5TFG 5TFI 5TFJ 5TGK 5UAK 6GJQ 6GJS 6GJU 6GK4 6GKD 6HEP 6MSM 6O1V 6O2P 6UK1	5JHO
Enriched GO Terms of Interacting Partners?
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