C11orf49 and FH

Data Source:
BioGRID (two hybrid)

		C11orf49	FH
Description		chromosome 11 open reading frame 49	fumarate hydratase
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Tricarboxylic Acid Cycle Enzyme Complex Extracellular Exosome
	Molecular Function	Protein Binding	Fumarate Hydratase Activity Protein Binding
	Biological Process		Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis
Pathways			Citric acid cycle (TCA cycle)
Drugs
Diseases			Renal cell carcinoma Multiple cutaneous and uterine leiomyomata Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) D-dimer levels ( 21502573) HDL cholesterol levels ( 32203549) Intraocular pressure ( 29617998) Neurociticism ( 29500382)	Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: ARHGEF15 CDC16 ENY2 FH GCA GSR PHF1 PNMA5 PRKAR1A PSMA1 RAB17 RAB29 RBM48 RPL8 RPS3A TXN2 UBE3A UBQLN4 ZFHX3	17 interacting genes: C11orf49 CCDC102B CCDC57 CCNDBP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19
Entrez ID		79096	2271
HPRD ID		08332	00652
Ensembl ID		ENSG00000149179	ENSG00000091483
Uniprot IDs		B4DUV7 Q9H6J7	A0A0S2Z4C3 P07954
PDB IDs			3E04 5D6B 5UPP 6EBT
Enriched GO Terms of Interacting Partners?
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