FH and KLHL6

		FH	KLHL6
Description		fumarate hydratase	kelch like family member 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Tricarboxylic Acid Cycle Enzyme Complex Extracellular Exosome
	Molecular Function	Fumarate Hydratase Activity Protein Binding	Protein Binding
	Biological Process	Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis	Germinal Center Formation B Cell Receptor Signaling Pathway
Pathways		Citric acid cycle (TCA cycle)
Drugs
Diseases		Renal cell carcinoma Multiple cutaneous and uterine leiomyomata Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)	Youthful appearance (self-reported) ( 32339537)
Interacting Genes		17 interacting genes: C11orf49 CCDC102B CCDC57 CCNDBP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19	7 interacting genes: BYSL CRY2 FH PPP1R1B RC3H2 SBDS TMPO
Entrez ID		2271	89857
HPRD ID		00652	10035
Ensembl ID		ENSG00000091483	ENSG00000172578
Uniprot IDs		A0A0S2Z4C3 P07954	Q8WZ60
PDB IDs		3E04 5D6B 5UPP 6EBT
Enriched GO Terms of Interacting Partners?
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