FH and TNPO2

Data Source:
BioGRID (two hybrid)

		FH	TNPO2
Description		fumarate hydratase	transportin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Tricarboxylic Acid Cycle Enzyme Complex Extracellular Exosome	Nucleus Cytoplasm
	Molecular Function	Fumarate Hydratase Activity Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis	Protein Import Into Nucleus
Pathways		Citric acid cycle (TCA cycle)
Drugs
Diseases		Renal cell carcinoma Multiple cutaneous and uterine leiomyomata Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)	Diffuse large B-cell lymphoma or multiple sclerosis ( 31407831)
Interacting Genes		17 interacting genes: C11orf49 CCDC102B CCDC57 CCNDBP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19	52 interacting genes: A1CF APIP BEND7 BIRC7 BIRC8 BLMH C12orf40 C1orf94 CAMK2B CAMK2D CAMK2G CCDC158 CRYAB CTAG1A CTAG1B ELAVL1 EXOC5 FH FTO FUCA2 GCH1 GSC2 KLHL2 KLHL20 KLHL3 KRT75 KRTAP8-1 NME1 NUP98 NXF1 OTX2 PACSIN3 PDLIM7 PIK3CD PINX1 PNMA5 POU6F2 PRMT8 PYCR1 RAN RBM45 RPL4 RPRD1B SERTAD3 SF1 TBX2 TCL1B TERF1 THAP6 TRIM8 ZBTB32 ZC2HC1C
Entrez ID		2271	30000
HPRD ID		00652	04301
Ensembl ID		ENSG00000091483	ENSG00000105576
Uniprot IDs		A0A0S2Z4C3 P07954	A0A024R7F7 O14787 Q05D48 Q4LE60
PDB IDs		3E04 5D6B 5UPP 6EBT
Enriched GO Terms of Interacting Partners?
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