FH and SAT1

Data Source:
BioGRID (two hybrid)

		FH	SAT1
Description		fumarate hydratase	spermidine/spermine N1-acetyltransferase 1
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GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Tricarboxylic Acid Cycle Enzyme Complex Extracellular Exosome	Cytosol
	Molecular Function	Fumarate Hydratase Activity Protein Binding	Diamine N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity Spermidine Binding Identical Protein Binding
	Biological Process	Tricarboxylic Acid Cycle Fumarate Metabolic Process Malate Metabolic Process DNA Repair Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cold-induced Thermogenesis	Angiogenesis Polyamine Biosynthetic Process Putrescine Catabolic Process Spermidine Acetylation
Pathways		Citric acid cycle (TCA cycle)	Interconversion of polyamines
Drugs			N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
Diseases		Renal cell carcinoma Multiple cutaneous and uterine leiomyomata Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency	Keratosis follicularis spinulosa decalvans
GWAS		Daytime sleep phenotypes ( 27126917) Major depressive disorder ( 27479909) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: C11orf49 CCDC102B CCDC57 CCNDBP1 DGCR6 EXOSC5 GRB2 H2AZ1 KLHL6 LMNB2 MDH2 PIM1 POLR1C PRKDC SAT1 TNPO2 TTC19	98 interacting genes: ABCB8 ABHD15 APLP1 B4GALT3 BHLHA9 C19orf25 CASP7 CCDC148 CCDC90B CCHCR1 CDC42EP1 CEP126 CHD3 COPS6 COX6C CRMP1 CSNK2A1 CSNK2A2 DDX39A DGKZ DIPK1B DMRT3 DNPEP EEF1G EIF3D EPHB6 ERG28 EVA1A FAM156A FAM228A FAM86C1P FH FTSJ3 FUNDC2 GAS2L2 GBP2 GDF9 HIF1A HOXB6 HOXB9 HSPB1 HSPE1 INO80C ITGA9 JUNB KAT5 KAT7 KCNA4 KHDC4 LHX3 LNX1 LRIF1 LUC7L2 LYRM7 MED31 MEOX2 MRPL12 MRPL9 MTA1 MYPOP NIF3L1 NMRK2 NTAQ1 PLGRKT PRDX2 PSMA1 PTN RACK1 RBM17 RBM48 REL RELA RPLP1 RPP25 SARAF SAT2 SEPHS1 SETDB1 SNAI2 TACO1 TCF25 TEAD4 TEX43 TLE1 TLE5 TNNI1 TP53 TP53TG1 TSC22D4 TUBB2A TXN2 UBE2D3 UNC119 USHBP1 UTP14A VASP VKORC1 ZHX1
Entrez ID		2271	6303
HPRD ID		00652	02431
Ensembl ID		ENSG00000091483	ENSG00000130066
Uniprot IDs		A0A0S2Z4C3 P07954	A0A384NQ10 P21673
PDB IDs		3E04 5D6B 5UPP 6EBT	2B3U 2B3V 2B4B 2B4D 2B58 2B5G 2F5I 2FXF 2G3T 2JEV
Enriched GO Terms of Interacting Partners?
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