MIS12 and NSL1

Data Source:
HPRD (in vivo, in vitro)

		MIS12	NSL1
Description		MIS12 kinetochore complex component	NSL1 component of MIS12 kinetochore complex
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleus Cytosol	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Cytosol Nuclear Speck
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Protein Localization To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly	Mitotic Sister Chromatid Segregation Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: CBX3 CBX5 DSN1 HSP90AA1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT	9 interacting genes: CBX1 CBX3 CBX5 DSN1 G6PC1 HSP90AA1 LRRK2 MIS12 SUGT1
Entrez ID		79003	25936
HPRD ID		12379	12378
Ensembl ID		ENSG00000167842	ENSG00000117697
Uniprot IDs		A8K1M4 Q9H081	Q53FM2 Q5SY74 Q96IY1
PDB IDs		5LSJ 5LSK	4NF9 5LSI 5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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