NSL1 and G6PC1

Data Source:
BioGRID (two hybrid)

		NSL1	G6PC1
Description		NSL1 component of MIS12 kinetochore complex	glucose-6-phosphatase catalytic subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Cytosol Nuclear Speck	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Glucose-6-phosphatase Activity Protein Binding Phosphotransferase Activity, Alcohol Group As Acceptor Phosphate Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation Cell Division	Glycogen Metabolic Process Glycogen Catabolic Process Gluconeogenesis Triglyceride Metabolic Process Steroid Metabolic Process Response To Carbohydrate Regulation Of Gene Expression Glucose-6-phosphate Transport Response To Food Cellular Response To Insulin Stimulus Multicellular Organism Growth Glucose Homeostasis Cholesterol Homeostasis Urate Metabolic Process Phosphorylated Carbohydrate Dephosphorylation Glucose 6-phosphate Metabolic Process Response To Resveratrol
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Glycogen storage disease type Ia (G6PC) Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS
Interacting Genes		9 interacting genes: CBX1 CBX3 CBX5 DSN1 G6PC1 HSP90AA1 LRRK2 MIS12 SUGT1	4 interacting genes: CDH16 FOXO1 NSL1 SNX13
Entrez ID		25936	2538
HPRD ID		12378	01983
Ensembl ID		ENSG00000117697	ENSG00000131482
Uniprot IDs		Q53FM2 Q5SY74 Q96IY1	P35575
PDB IDs		4NF9 5LSI 5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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