NSL1 and MIS12

Data Source:
HPRD (in vivo, in vitro)

		NSL1	MIS12
Description		NSL1 component of MIS12 kinetochore complex	MIS12 kinetochore complex component
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Cytosol Nuclear Speck	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleus Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Cell Division	Mitotic Sister Chromatid Segregation Chromosome Segregation Protein Localization To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CBX1 CBX3 CBX5 DSN1 G6PC1 HSP90AA1 LRRK2 MIS12 SUGT1	10 interacting genes: CBX3 CBX5 DSN1 HSP90AA1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		25936	79003
HPRD ID		12378	12379
Ensembl ID		ENSG00000117697	ENSG00000167842
Uniprot IDs		Q53FM2 Q5SY74 Q96IY1	A8K1M4 Q9H081
PDB IDs		4NF9 5LSI 5LSJ 5LSK	5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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