MIS12 and PMF1

Data Source:
HPRD (in vitro, in vivo)

		MIS12	PMF1
Description		MIS12 kinetochore complex component	polyamine modulated factor 1
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GO Annotations	Cellular Component	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleus Cytosol	MIS12/MIND Type Complex Condensed Chromosome Kinetochore Nuclear MIS12/MIND Complex Nucleoplasm Transcription Regulator Complex Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Transcription Coactivator Activity Protein Binding Leucine Zipper Domain Binding
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Protein Localization To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly	Transcription By RNA Polymerase II Cell Cycle Chromosome Segregation Positive Regulation Of Transcription, DNA-templated Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Abstraction and mental flexibility ( 31596458) Metabolite levels ( 23823483)	Estimated glomerular filtration rate ( 30604766) Intracerebral hemorrhage ( 24656865) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Longevity (age >99th survival percentile) ( 31413261) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Stroke ( 29531354) White matter hyperintensity burden ( 25663218)
Interacting Genes		10 interacting genes: CBX3 CBX5 DSN1 HSP90AA1 KNL1 NDC80 NSL1 PMF1 SUGT1 ZWINT	24 interacting genes: BICD2 CEP126 COPS6 COPS7A COPS7B CRMP1 DSN1 EFHC1 FBXO28 GDF9 GIT1 HSP90AA1 KDM1A MED31 MESD MIS12 NFE2L2 PTN SHC3 SUGT1 TBC1D21 TCP10L TSNAX USHBP1
Entrez ID		79003	11243
HPRD ID		12379	11441
Ensembl ID		ENSG00000167842	ENSG00000160783
Uniprot IDs		A8K1M4 Q9H081	Q6P1K2
PDB IDs		5LSJ 5LSK	5LSJ 5LSK
Enriched GO Terms of Interacting Partners?
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