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DDX58 and UBE2D3
Data Source:
BioGRID
(enzymatic study)
DDX58
UBE2D3
Description
DExD/H-box helicase 58
ubiquitin conjugating enzyme E2 D3
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Bicellular Tight Junction
Actin Cytoskeleton
Ruffle Membrane
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Extracellular Exosome
Molecular Function
RNA Helicase Activity
Double-stranded RNA Binding
Single-stranded RNA Binding
Protein Binding
ATP Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Positive Regulation Of Defense Response To Virus By Host
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
Detection Of Virus
Response To Virus
Positive Regulation Of Gene Expression
Viral Process
Protein Deubiquitination
Regulation Of Cell Migration
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Type III Interferon Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus
RIG-I Signaling Pathway
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Defense Response To Virus
Positive Regulation Of Response To Cytokine Stimulus
Cellular Response To Exogenous DsRNA
Antiviral Innate Immune Response
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
DNA Repair
Cellular Protein Modification Process
Protein Monoubiquitination
Protein Targeting To Peroxisome
Apoptotic Process
Protein Ubiquitination
BMP Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Cadmium Ion
Cellular Response To Mercury Ion
Positive Regulation Of Protein Targeting To Mitochondrion
Pathways
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Ub-specific processing proteases
Ovarian tumor domain proteases
OAS antiviral response
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Bone mineral density (spine) and age at menarche (
26312577
)
Hematocrit (
27863252
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Inflammatory skin disease (
25574825
)
Metabolite levels (
23823483
)
Psoriasis (
25903422
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Red blood cell count (
27863252
)
Asthma and attention deficit hyperactivity disorder (
31619474
)
Diastolic blood pressure (
30224653
)
Interacting Genes
16 interacting genes:
CYLD
MAVS
PRKCG
RNF122
RNF135
SNX5
THAP12
TRIM25
TRIM40
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2K
USP15
USP3
224 interacting genes:
AMBRA1
AMFR
ANAPC11
AREL1
ARIH1
ARIH2
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRCA1
CADPS2
CBL
CBLC
CHFR
CNOT4
CSNK2A1
CUL4B
DBN1
DCUN1D1
DDX58
DTX1
DTX2
DTX3
DTX3L
DVL2
DZIP3
EPS15
ERGIC3
ESR1
F12
FBXL12
FBXL17
FBXL2
FBXO2
FBXO25
FBXO7
FBXW11
FBXW8
FOCAD
FZR1
H2AC4
H3C1
H4C1
HDAC6
HECTD1
HECW1
HECW2
HERC1
HERC2
HUWE1
IKBKG
ITCH
KAT2B
KDM1B
LRSAM1
MAEA
MAP3K1
MAPT
MARCHF3
MARCHF5
MARCHF7
MARCHF8
MAST1
MDM2
MDM4
MEX3B
MEX3C
MGRN1
MIB1
MID1
MID2
MKRN1
MKRN3
MSL1
MSL2
MUL1
MYCBP2
MYLIP
NBR1
NEDD4
NEDD4L
NFKB1
NFKBIA
NHLRC1
NOSIP
OTUB1
PCGF1
PCGF2
PCGF3
PCGF5
PCGF6
PCNA
PDCD5
PELI1
PER2
PJA1
PJA2
POLL
POLM
PRPF19
PTEN
RABGEF1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RING1
RLIM
RMND5B
RNF10
RNF103
RNF111
RNF114
RNF115
RNF122
RNF125
RNF126
RNF13
RNF130
RNF14
RNF150
RNF165
RNF166
RNF167
RNF168
RNF181
RNF185
RNF19B
RNF2
RNF216
RNF220
RNF25
RNF26
RNF31
RNF38
RNF4
RNF41
RNF43
RNF5
RNF8
RNFT1
RPLP1
RSPRY1
SAT1
SH3RF1
SHOC2
SIAH1
SIAH2
SMURF1
SMURF2
SOX2
SQSTM1
ST7
STAM2
STAU1
STK25
STUB1
SYVN1
TMEM129
TOPORS
TP53
TP73
TRAF6
TRAIP
TRIM10
TRIM17
TRIM2
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM31
TRIM32
TRIM33
TRIM35
TRIM37
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM58
TRIM62
TRIM63
TRIM68
TRIM69
TRIM7
TRIM72
TRIM8
TUBA1A
UBA1
UBA6
UBASH3B
UBE2O
UBE3A
UBE3C
UBE4A
UBE4B
UBOX5
UBR5
UBTD1
UFM1
UHRF1
USP7
UVSSA
WBP2
WSB1
WWP1
WWP2
XIAP
XPNPEP1
ZNRF1
ZNRF2
ZNRF4
Entrez ID
23586
7323
HPRD ID
13131
04269
Ensembl ID
ENSG00000107201
ENSG00000109332
Uniprot IDs
O95786
A0A024RDH2
D6RAH7
P61077
PDB IDs
2LWD
2LWE
2QFB
2QFD
2RMJ
2YKG
3LRN
3LRR
3NCU
3OG8
3ZD6
3ZD7
4AY2
4BPB
4NQK
4ON9
4P4H
5E3H
5F98
5F9F
5F9H
6GPG
6KYV
1X23
2FUH
3L1Z
3RPG
3UGB
4BVU
4R8P
4S3O
5EGG
5IFR
6CP0
6T7F
Enriched GO Terms of Interacting Partners
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