MKRN3 and TLE5

Data Source:
BioGRID (two hybrid, two hybrid)

		MKRN3	TLE5
Description		makorin ring finger protein 3	TLE family member 5, transcriptional modulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ribonucleoprotein Complex	Nucleus Transcription Regulator Complex
	Molecular Function	Protein Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Multicellular Organism Development Animal Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis
Pathways			Repression of WNT target genes
Drugs
Diseases
GWAS		Height ( 31562340) Menarche (age at onset) ( 25231870) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		178 interacting genes: ACOT11 ADAMTSL4 ADRA2C ANKRD11 ANTKMT APEX2 AQP1 ARID5A ARMC5 AVPI1 BATF2 BCL2L11 BEX2 BLZF1 BPIFA1 C10orf82 C21orf58 CCDC120 CCDC185 CCDC187 CCDC33 CDCA4 CEP70 CERCAM CRACR2A CYSRT1 DDIT4L ECM1 ECSIT EFEMP1 ENKD1 ERCC1 FAM110A FAM124B FAM214B FARS2 GADD45GIP1 GATA1 GEM GOLGA6A GRAP2 HCK HGS HOXA1 HOXD12 HSF2BP HSF4 IGF1 IKZF3 INO80B KANK2 KIF1A KIFC3 KLF1 KLHL38 KRT34 KRT75 KRT86 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP6-2 KRTAP7-1 KRTAP8-1 LAGE3 LASP1 LRSAM1 MAGED1 MBD3 MCCD1 MDM2 MDM4 MEOX1 MEOX2 MGAT5B MIF4GD MNAT1 MORN3 MRPL38 MRPS6 MYOZ2 NABP1 NDE1 NDUFB7 NKAPD1 NME4 ODAD4 ODF3B PEX10 PEX5 PKN1 POLR1C POMC PRKAA2 PRPF31 PRR22 PRR35 PSMA1 PSMB1 PTH1R PTK6 RASD1 RBM41 RBPMS RBPMS2 RIBC1 RNF166 RNF32 RNF7 RSPO4 RTP5 SCNM1 SF1 SFN SLPI SMARCD1 SMYD3 SNRPC SORBS3 SPATA8 STH STMN3 STN1 SYNGAP1 TADA2A TASOR2 TCEA2 TCHP TCL1B TENT5B TFAP2A TFIP11 TLE5 TPRX1 TRAF2 TRIM23 TRIM31 TRIM34 TRIM5 TRIM65 TRIM8 TSG101 TSGA10IP TSPAN4 TTC23 TXNDC11 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L3 UBE2N UBE2U UBE2V1 UBE2V2 UBE2W UQCC2 USHBP1 VPS9D1 WDR25 WWOX YPEL3 ZBTB42 ZFC3H1 ZFP57 ZIM2 ZNF34 ZNF414 ZNF587 ZNF688 ZNF835	362 interacting genes: ABI2 AEN AGR2 AKAP8L ANAPC11 ANKRD11 AR ARHGAP32 ASB3 ATN1 ATP6V0D1 BAG4 BAHD1 BCL6 BHLHE40 BIRC7 BPIFA1 BYSL C10orf55 C11orf1 C14orf119 C19orf54 C1orf109 C1orf216 C1orf94 C2CD6 C7orf57 CABP2 CABP4 CABP5 CALCOCO2 CAPN1 CARD9 CCDC120 CCDC57 CCL7 CCNJL CCNK CCNO CFAP206 CIB3 CLIC3 CLIP3 CNFN COA7 CPSF7 CRACR2A CRX CSNK2A1 CSTF2 CSTF2T CT55 CTBP2 CYSRT1 DAZAP2 DCUN1D1 DDX6 DGCR6 DIP2A DMRT2 DMRT3 DMRTB1 DNMT3L DOK6 DVL2 DVL3 DYDC1 EAF1 EAF2 EFEMP2 EFHC1 EIF1AD EIF4E2 ERF EXOSC5 EYA2 FAM124A FAM124B FAM168B FAM214B FAM217B FAM90A1 FANCG FBF1 FCHSD2 FHL3 FOSB FOXD2 FOXN1 FOXP2 FRS3 FSD2 GABARAP GATA1 GCC1 GEM GFAP GFI1B GIGYF1 GLIS2 GLRX3 GOLGA2 GOLGA6L9 GORASP2 GPANK1 GPATCH2L GRAP2 GRB2 GRN GTF2E1 GYS1 HDAC4 HDHD3 HELT HEXIM2 HGS HHEX HMGB1 HNF1A HNRNPF HNRNPH2 HNRNPK HNRNPLL HOMEZ HOXA1 HOXB5 HOXC8 HOXC9 IKZF3 INO80B INO80E INPP5J IRX2 IRX6 KANK2 KDM1A KIFC3 KLF1 KLF4 KLHDC7B KRT13 KRT15 KRT31 KRT34 KRT35 KRT40 KRTAP10-11 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 L3MBTL2 LDLR LDOC1 LENG8 LHX3 LINC00526 LMO1 LMO2 LMO4 LSM2 LZTS2 MAGOHB MAPK1 MAPK14 MAPRE3 MBNL1 MCRS1 MDFI MED12L MED25 MED31 MED4 MEIS3 MFAP1 MIA2 MIIP MKRN3 MLH1 MLLT6 MLX MORF4L1 MORF4L2 MSS51 MSX1 MSX2 MTUS2 MVP MYF5 MYH7B MYO15B MYOG NAB2 NAF1 NBPF19 NCDN NDOR1 NDUFB7 NEK6 NOTCH2NLA NTAQ1 NUDT22 NUTF2 NUTM1 OLIG3 OSGIN1 OXER1 P4HA3 PARVG PATZ1 PAX8 PAX9 PCBP1 PCSK5 PFDN5 PHF1 PICK1 PITX1 PITX2 PLAGL1 POLR1C POU2F1 PPP1R16A PPP1R16B PRDM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRKAB2 PROP1 PRPF31 PRR3 PRR35 PSMB1 PSMB4 PSMF1 PTRH2 QARS1 RAD51D RBM10 RBPMS REL RELA RFX6 RHOXF2 RIBC1 RIMBP3 RIPPLY1 RNF31 RORB RPL18A RUNX1 RUSC1 SAT1 SCNM1 SDCBP SERTAD3 SET SF3B4 SH2B2 SH3GL3 SHFL SHISA6 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SMAD4 SMARCB1 SMARCD1 SNCAIP SNRPA SNRPC SOHLH1 SOX5 SPATA25 SPG21 SRPK2 SSC4D STK16 STX11 SUFU SUPT5H TBX3 TBX6 TCEANC TCF4 TCF7L2 TEAD4 TENT5B TEX37 TFAP2D THAP7 TIGD3 TMCC2 TNS2 TOX3 TRAF1 TRAF2 TRIB3 TRIM26 TRIM27 TRIM41 TRIP6 TRMT2A TSC1 TSC22D4 TSEN15 TSGA10 TSGA10IP TSSK3 TTC23 U2AF2 UBAP2 UBE2H UBL5 UBXN11 USP2 USP54 VEZF1 VGLL1 VIM VPS37B VPS37C YPEL3 YTHDF1 ZBTB16 ZBTB24 ZBTB47 ZFHX3 ZGPAT ZIC1 ZMYND12 ZNF330 ZNF34 ZNF383 ZNF408 ZNF414 ZNF417 ZNF467 ZNF48 ZNF503 ZNF524 ZNF576 ZNF688 ZNF792 ZNF835 ZRANB1
Entrez ID		7681	166
HPRD ID		04836	02556
Ensembl ID		ENSG00000179455	ENSG00000104964
Uniprot IDs		Q13064	Q08117 Q8WY48
PDB IDs
Enriched GO Terms of Interacting Partners?
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