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MKRN3 and UBE2K
Data Source:
BioGRID
(two hybrid)
MKRN3
UBE2K
Description
makorin ring finger protein 3
ubiquitin conjugating enzyme E2 K
Image
No pdb structure
GO Annotations
Cellular Component
Ribonucleoprotein Complex
Nucleus
Cytosol
Filopodium Tip
Molecular Function
Protein Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Protein Polyubiquitination
Protein Ubiquitination
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-threonine Phosphorylation
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Interferon-beta
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Protein K48-linked Ubiquitination
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Height (
31562340
)
Menarche (age at onset) (
25231870
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Plasma amyloid beta peptide concentrations (ABx-40) (
24535457
)
Platelet count (
32888494
)
Interacting Genes
178 interacting genes:
ACOT11
ADAMTSL4
ADRA2C
ANKRD11
ANTKMT
APEX2
AQP1
ARID5A
ARMC5
AVPI1
BATF2
BCL2L11
BEX2
BLZF1
BPIFA1
C10orf82
C21orf58
CCDC120
CCDC185
CCDC187
CCDC33
CDCA4
CEP70
CERCAM
CRACR2A
CYSRT1
DDIT4L
ECM1
ECSIT
EFEMP1
ENKD1
ERCC1
FAM110A
FAM124B
FAM214B
FARS2
GADD45GIP1
GATA1
GEM
GOLGA6A
GRAP2
HCK
HGS
HOXA1
HOXD12
HSF2BP
HSF4
IGF1
IKZF3
INO80B
KANK2
KIF1A
KIFC3
KLF1
KLHL38
KRT34
KRT75
KRT86
KRTAP19-2
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-2
KRTAP7-1
KRTAP8-1
LAGE3
LASP1
LRSAM1
MAGED1
MBD3
MCCD1
MDM2
MDM4
MEOX1
MEOX2
MGAT5B
MIF4GD
MNAT1
MORN3
MRPL38
MRPS6
MYOZ2
NABP1
NDE1
NDUFB7
NKAPD1
NME4
ODAD4
ODF3B
PEX10
PEX5
PKN1
POLR1C
POMC
PRKAA2
PRPF31
PRR22
PRR35
PSMA1
PSMB1
PTH1R
PTK6
RASD1
RBM41
RBPMS
RBPMS2
RIBC1
RNF166
RNF32
RNF7
RSPO4
RTP5
SCNM1
SF1
SFN
SLPI
SMARCD1
SMYD3
SNRPC
SORBS3
SPATA8
STH
STMN3
STN1
SYNGAP1
TADA2A
TASOR2
TCEA2
TCHP
TCL1B
TENT5B
TFAP2A
TFIP11
TLE5
TPRX1
TRAF2
TRIM23
TRIM31
TRIM34
TRIM5
TRIM65
TRIM8
TSG101
TSGA10IP
TSPAN4
TTC23
TXNDC11
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2L3
UBE2N
UBE2U
UBE2V1
UBE2V2
UBE2W
UQCC2
USHBP1
VPS9D1
WDR25
WWOX
YPEL3
ZBTB42
ZFC3H1
ZFP57
ZIM2
ZNF34
ZNF414
ZNF587
ZNF688
ZNF835
95 interacting genes:
AMFR
ANAPC11
BARD1
BFAR
BIRC7
BIRC8
BRCA1
CASP12
CBLC
CCNC
CDC6
DDI1
DDX58
DIABLO
DTX3
DTX3L
DZIP3
EXOSC7
FZR1
HTT
ITCH
ITSN1
KRIT1
LRSAM1
MAP3K1
MARCHF3
MARCHF7
MDM2
MEOX2
MID1
MID2
MIPOL1
MKRN2
MKRN3
NEDD4L
NEDD8
NFKB1
NUB1
PAX6
PIAS4
PICK1
PJA1
PRKN
PRPF40A
PRRG4
RBCK1
RC3H2
REL
RING1
RLIM
RNF111
RNF114
RNF125
RNF138
RNF144A
RNF166
RNF167
RNF182
RNF183
RNF185
RNF2
RNF31
RNF32
RNF4
RNF41
RNF5
SDCBP
SENP1
SH3RF1
SIAH1
SMURF1
TP53
TRAF7
TRAIP
TRIM2
TRIM27
TRIM3
TRIM31
TRIM34
TRIM35
TRIM39
TRIM43
TRIM5
TRIM50
TRIM63
TSN
UBA1
UBB
UBE2I
UBOX5
UHRF2
USP1
WWP2
ZDHHC17
ZNF384
Entrez ID
7681
3093
HPRD ID
04836
04165
Ensembl ID
ENSG00000179455
ENSG00000078140
Uniprot IDs
Q13064
B3KSH4
B4DIZ2
P61086
PDB IDs
1YLA
2O25
3E46
3F92
3K9O
3K9P
5DFL
6IF1
6JB6
6JB7
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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