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MKRN3 and SFN
Data Source:
BioGRID
(two hybrid, two hybrid)
MKRN3
SFN
Description
makorin ring finger protein 3
stratifin
Image
No pdb structure
GO Annotations
Cellular Component
Ribonucleoprotein Complex
Extracellular Space
Nucleus
Mitochondrion
Cytosol
Extracellular Exosome
Molecular Function
Protein Binding
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Kinase Binding
Identical Protein Binding
Cadherin Binding
Phosphoprotein Binding
Biological Process
Protein Polyubiquitination
Protein Ubiquitination
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Release Of Cytochrome C From Mitochondria
Keratinocyte Development
Negative Regulation Of Protein Kinase Activity
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Epidermal Cell Division
Negative Regulation Of Keratinocyte Proliferation
Positive Regulation Of Cell Growth
Keratinization
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Epidermal Cell Differentiation
Positive Regulation Of Protein Export From Nucleus
Membrane Organization
Establishment Of Skin Barrier
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Drugs
Diseases
GWAS
Height (
31562340
)
Menarche (age at onset) (
25231870
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Eosinophil percentage of white cells (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Interacting Genes
178 interacting genes:
ACOT11
ADAMTSL4
ADRA2C
ANKRD11
ANTKMT
APEX2
AQP1
ARID5A
ARMC5
AVPI1
BATF2
BCL2L11
BEX2
BLZF1
BPIFA1
C10orf82
C21orf58
CCDC120
CCDC185
CCDC187
CCDC33
CDCA4
CEP70
CERCAM
CRACR2A
CYSRT1
DDIT4L
ECM1
ECSIT
EFEMP1
ENKD1
ERCC1
FAM110A
FAM124B
FAM214B
FARS2
GADD45GIP1
GATA1
GEM
GOLGA6A
GRAP2
HCK
HGS
HOXA1
HOXD12
HSF2BP
HSF4
IGF1
IKZF3
INO80B
KANK2
KIF1A
KIFC3
KLF1
KLHL38
KRT34
KRT75
KRT86
KRTAP19-2
KRTAP19-6
KRTAP19-7
KRTAP21-2
KRTAP6-2
KRTAP7-1
KRTAP8-1
LAGE3
LASP1
LRSAM1
MAGED1
MBD3
MCCD1
MDM2
MDM4
MEOX1
MEOX2
MGAT5B
MIF4GD
MNAT1
MORN3
MRPL38
MRPS6
MYOZ2
NABP1
NDE1
NDUFB7
NKAPD1
NME4
ODAD4
ODF3B
PEX10
PEX5
PKN1
POLR1C
POMC
PRKAA2
PRPF31
PRR22
PRR35
PSMA1
PSMB1
PTH1R
PTK6
RASD1
RBM41
RBPMS
RBPMS2
RIBC1
RNF166
RNF32
RNF7
RSPO4
RTP5
SCNM1
SF1
SFN
SLPI
SMARCD1
SMYD3
SNRPC
SORBS3
SPATA8
STH
STMN3
STN1
SYNGAP1
TADA2A
TASOR2
TCEA2
TCHP
TCL1B
TENT5B
TFAP2A
TFIP11
TLE5
TPRX1
TRAF2
TRIM23
TRIM31
TRIM34
TRIM5
TRIM65
TRIM8
TSG101
TSGA10IP
TSPAN4
TTC23
TXNDC11
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2L3
UBE2N
UBE2U
UBE2V1
UBE2V2
UBE2W
UQCC2
USHBP1
VPS9D1
WDR25
WWOX
YPEL3
ZBTB42
ZFC3H1
ZFP57
ZIM2
ZNF34
ZNF414
ZNF587
ZNF688
ZNF835
56 interacting genes:
ABL1
ARAF
BAD
BAX
BCR
BRAF
CCAR1
CCDC102B
CCDC125
CCNH
CDC25B
CDK1
CHST1
COP1
DUXAP9
EEF1A1
EGFR
EIF2S1
EIF4B
EXO1
FAM189A2
FAM53C
FAM9B
FOXO1
FOXO4
GPRIN2
HDAC5
HNRNPD
ING1
KCNK15
KCNK3
KCNK9
KIAA0408
LNX2
LONRF1
MAGEA1
MAP3K5
MARK3
MDM4
MKRN3
MST1R
NR3C1
NTAQ1
PAX9
PLEKHF2
PLK4
RAB3IP
RFFL
SAMSN1
TBL3
TP53
TRIM25
TSC2
YWHAG
ZC2HC1C
ZFP36
Entrez ID
7681
2810
HPRD ID
04836
03185
Ensembl ID
ENSG00000179455
ENSG00000175793
Uniprot IDs
Q13064
P31947
PDB IDs
1YWT
1YZ5
3IQJ
3IQU
3IQV
3LW1
3MHR
3O8I
3P1N
3P1O
3P1P
3P1Q
3P1R
3P1S
3SMK
3SML
3SMM
3SMN
3SMO
3SP5
3SPR
3T0L
3T0M
3U9X
3UX0
4DAT
4DAU
4DHM
4DHN
4DHO
4DHP
4DHQ
4DHR
4DHS
4DHT
4DHU
4FL5
4FR3
4IEA
4JC3
4JDD
4QLI
4Y32
4Y3B
4Y5I
5BTV
5HF3
5LTW
5LU1
5LU2
5MHC
5MOC
5MXO
5MY9
5MYC
5N5R
5N5T
5N5W
5N75
5OEG
5OEH
5OK9
5OKF
5OM0
5OMA
6FAU
6FAV
6FAW
6FBB
6FBW
6FBY
6FCP
6FI4
6FI5
6G6X
6G8I
6G8J
6G8K
6G8L
6G8P
6G8Q
6GHP
6HHP
6HKB
6HKF
6HMT
6HMU
6HN2
6NV2
6QDR
6QDS
6QDT
6QDU
6QHL
6QHM
6QIU
6QZR
6QZS
6R5L
6RHC
6RJL
6RJQ
6RJZ
6RK8
6RKI
6RKK
6RKM
6RL3
6RL4
6RL6
6RM5
6RM7
6RP6
6RWH
6RWI
6RWS
6RWU
6RX2
6S39
6S3C
6S40
6S9Q
6SIN
6SIO
6SIP
6SIQ
6SLV
6SLW
6SLX
6TCH
6TJM
6TL3
6TLF
6TLG
6TM7
6TWZ
6W0L
6XWD
6Y1J
6Y3M
6Y3O
6Y3R
6Y3S
6Y3V
6Y40
6Y44
6Y8A
6Y8B
6Y8D
6Y8E
6YOW
6YOX
6YOY
6YP2
6YP3
6YP8
6YPL
6YPY
6YQ2
7AEW
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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