WAS and PSTPIP1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		WAS	PSTPIP1
Description		WASP actin nucleation promoting factor	proline-serine-threonine phosphatase interacting protein 1
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GO Annotations	Cellular Component	Nucleus Cytosol Actin Filament Plasma Membrane Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Site Of Double-strand Break Phagocytic Vesicle Extracellular Exosome	Uropod Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase Binding GTPase Regulator Activity Small GTPase Binding Identical Protein Binding Phospholipase Binding	Protein Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Regulation Of T Cell Antigen Processing And Presentation Defense Response Immune Response Rho Protein Signal Transduction Blood Coagulation Regulation Of Actin Polymerization Or Depolymerization Actin Polymerization Or Depolymerization Epidermis Development Regulation Of Lamellipodium Assembly Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Cdc42 Protein Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Protein-containing Complex Assembly Cellular Response To Interferon-gamma Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Actin Filament Polymerization Innate Immune Response
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs		(S)-wiskostatin
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia	Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS		Platelet distribution width ( 32888494)	Neurofibrillary tangles ( 31497858) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		56 interacting genes: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 DVL2 ENAH EVL FCHSD2 FGR FYB1 FYN GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RANBP2 RGS14 RHOJ SNX9 SORBS2 SRC TCERG1 TEC TNK2 TRIP10 UBASH3A VASP WBP4 WIPF1 WIPF2	64 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 CWF19L2 DHX40 DNM2 EHHADH EXOC5 FAM90A1 FASLG FBXL18 HAPLN2 HHEX HMG20A HSF2BP IL16 KANK2 KHDRBS1 LIN37 LSM4 MCRS1 MEFV MOS MVP NAV2 NCBP1 PCDHB14 PNKP PRPF31 PRR35 PTPN12 PTPN18 RINT1 RNPS1 RPL9 RTP5 RXRB SCNM1 SDCBP SH2D4A SHBG SMARCD1 SPG7 SYCE1 TFIP11 TPH1 TRAF3IP3 TSGA10IP TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZC2HC1C ZNF175 ZNF408 ZNF580 ZNF688
Entrez ID		7454	9051
HPRD ID		02314	05891
Ensembl ID		ENSG00000015285	ENSG00000140368
Uniprot IDs		A0A024QYX8 P42768	A0A0S2Z5P3 O43586
PDB IDs		1CEE 1EJ5 1T84 2A3Z 2K42 2OT0	2DIL
Enriched GO Terms of Interacting Partners?
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