Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
WAS and ITK
Data Source:
HPRD
(in vitro, in vivo)
WAS
ITK
Description
WASP actin nucleation promoting factor
IL2 inducible T cell kinase
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Actin Filament
Plasma Membrane
Cell-cell Junction
Vesicle Membrane
Actin Cytoskeleton
Site Of Double-strand Break
Phagocytic Vesicle
Extracellular Exosome
Nucleus
Cytosol
Plasma Membrane
Cell-cell Junction
Molecular Function
Actin Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
GTPase Regulator Activity
Small GTPase Binding
Identical Protein Binding
Phospholipase Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
Biological Process
Regulation Of T Cell Antigen Processing And Presentation
Defense Response
Immune Response
Rho Protein Signal Transduction
Blood Coagulation
Regulation Of Actin Polymerization Or Depolymerization
Actin Polymerization Or Depolymerization
Epidermis Development
Regulation Of Lamellipodium Assembly
Endosomal Transport
Actin Filament Polymerization
Actin Filament-based Movement
Cdc42 Protein Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Catalytic Activity
T Cell Receptor Signaling Pathway
Regulation Of Stress Fiber Assembly
Negative Regulation Of Stress Fiber Assembly
Protein-containing Complex Assembly
Cellular Response To Interferon-gamma
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Cell Motility
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Cytokine Production
NK T Cell Differentiation
Adaptive Immune Response
Cellular Defense Response
Signal Transduction
Activation Of Phospholipase C Activity
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
T Cell Activation
Gamma-delta T Cell Activation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Pathways
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Generation of second messenger molecules
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Drugs
(S)-wiskostatin
Staurosporine
Pazopanib
Fostamatinib
Zanubrutinib
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS
Platelet distribution width (
32888494
)
Asthma (
31959851
)
Daytime sleep phenotypes (
27126917
)
Eosinophil counts (
32888494
)
Heel bone mineral density (
30598549
)
Personality traits in bipolar disorder (
21368711
)
T-Cell Immunoglobulin and Mucin domain 1 levels (
32460577
)
Interacting Genes
56 interacting genes:
ABI3
ACTC1
APBB1
APPBP2
ARHGAP1
ARHGEF7
ARPC1B
ARPC2
ARPC3
BAIAP2L1
BTK
C5AR1
CDC42
CIB1
CRKL
CSNK2A1
CSNK2A2
DLG1
DVL2
ENAH
EVL
FCHSD2
FGR
FYB1
FYN
GRB2
HCK
HCLS1
ITK
ITSN2
LCK
LCP2
NCK1
NCK2
NCKIPSD
PIK3R1
PLCG1
PRPF40A
PSTPIP1
PTPN12
RAC1
RANBP2
RGS14
RHOJ
SNX9
SORBS2
SRC
TCERG1
TEC
TNK2
TRIP10
UBASH3A
VASP
WBP4
WIPF1
WIPF2
34 interacting genes:
BLNK
BMX
BTK
CBL
CD28
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FYN
GAB1
GRB2
HNRNPK
IKBKG
KHDRBS1
KPNA2
LAT
LCK
LCP2
MET
PLCG1
PLCG2
PPIA
SH2D2A
SMAD4
SMURF1
SOCS1
SPRR2A
SRC
TGFBR1
WAS
Entrez ID
7454
3702
HPRD ID
02314
01746
Ensembl ID
ENSG00000015285
ENSG00000113263
Uniprot IDs
A0A024QYX8
P42768
Q08881
PDB IDs
1CEE
1EJ5
1T84
2A3Z
2K42
2OT0
1SM2
1SNU
1SNX
2E6I
2LMJ
2YUQ
3MIY
3MJ1
3MJ2
3QGW
3QGY
3T9T
3V5J
3V5L
3V8T
3V8W
4HCT
4HCU
4HCV
4KIO
4L7S
4M0Y
4M0Z
4M12
4M13
4M14
4M15
4MF0
4MF1
4PP9
4PPA
4PPB
4PPC
4PQN
4QD6
4RFM
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?