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SMAD9 and HEY1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SMAD9
HEY1
Description
SMAD family member 9
hes related family bHLH transcription factor with YRPW motif 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
I-SMAD Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Cell Differentiation
BMP Signaling Pathway
SMAD Protein Signal Transduction
Cellular Response To BMP Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Pulmonary Valve Morphogenesis
Atrioventricular Valve Formation
Endocardial Cushion Morphogenesis
Cardiac Ventricle Morphogenesis
Regulation Of Transcription By RNA Polymerase II
Notch Signaling Pathway
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Dorsal Aorta Morphogenesis
Umbilical Cord Morphogenesis
Negative Regulation Of Neuron Differentiation
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Neurogenesis
Cardiac Epithelial To Mesenchymal Transition
Heart Trabecula Formation
Cardiac Septum Morphogenesis
Ventricular Septum Morphogenesis
Labyrinthine Layer Blood Vessel Development
Arterial Endothelial Cell Differentiation
Notch Signaling Involved In Heart Development
Negative Regulation Of Biomineral Tissue Development
Cellular Response To Glucocorticoid Stimulus
Circulatory System Development
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation
Regulation Of Vasculogenesis
Pathways
Signaling by BMP
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS
Coronary artery disease (
29212778
)
Heel bone mineral density (
30598549
28869591
)
Perioperative myocardial infarction in coronary artery bypass surgery (
25948407
)
Spontaneous preterm birth (preterm birth) (
25599974
)
Total body bone mineral density (
29304378
)
Interacting Genes
117 interacting genes:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MACO1
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS1
RANBP9
RFX1
RMND5A
RNF123
RRBP1
RUBCN
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TOB1
TRIM29
TRIP12
TTC37
TWNK
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
22 interacting genes:
ARNT
CREBZF
DAZAP2
FBXW7
FOXH1
GATA1
HES1
HEY2
KRTAP6-2
LAPTM5
MDM2
MYOD1
NTRK3
PITX2
PLEKHB2
PRKD2
SKIL
SMAD3
SMAD9
TENT5D
TP53
YTHDF1
Entrez ID
4093
23462
HPRD ID
04484
04260
Ensembl ID
ENSG00000120693
ENSG00000164683
Uniprot IDs
A0A024RDR3
O15198
B4DEI9
Q9Y5J3
PDB IDs
6FZT
2DB7
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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