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SMAD9 and TOB1
Data Source:
HPRD
(in vivo)
SMAD9
TOB1
Description
SMAD family member 9
transducer of ERBB2, 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Nucleus
Cytoplasm
CCR4-NOT Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
I-SMAD Binding
Transcription Corepressor Activity
Protein Binding
Receptor Tyrosine Kinase Binding
SMAD Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Cell Differentiation
BMP Signaling Pathway
SMAD Protein Signal Transduction
Cellular Response To BMP Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Negative Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Negative Regulation Of Translation
Negative Regulation Of BMP Signaling Pathway
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways
Signaling by BMP
Drugs
Diseases
GWAS
Coronary artery disease (
29212778
)
Heel bone mineral density (
30598549
28869591
)
Perioperative myocardial infarction in coronary artery bypass surgery (
25948407
)
Spontaneous preterm birth (preterm birth) (
25599974
)
Total body bone mineral density (
29304378
)
Blood protein levels (
28240269
)
Interacting Genes
117 interacting genes:
ABTB1
ACTB
ACVR1
AFF1
AP2A1
ARHGAP9
ARID1B
ARNT
ASB2
ASH2L
BAZ1A
BTG2
CAMSAP1
CEP135
CHPF
CLPB
CPXM2
CSH1
CSH2
CTR9
CXXC5
CYP11A1
DIAPH3
DKK1
DNAJA3
DNAJC7
DST
DSTN
E4F1
EIF3C
EIF3E
EIF3F
ERVV-1
EVC2
EXPH5
FLI1
FN1
FTL
GRN
HEY1
HEYL
HUWE1
KDM1A
KDM6A
KMT2D
LEMD3
LMO4
LNPEP
LRP5
MACO1
MAN1A2
MAN1C1
MAN2B1
MBD1
MCM3AP
METAP1
MGAT1
MTMR10
MTMR11
NAGK
OTUB1
PABPC4
PAPPA
PELP1
PHKA2
PIR
PKP2
PLEC
PNPLA2
PPARD
PPP2R5E
PRMT6
PSAP
PSMD8
QARS1
RANBP9
RFX1
RMND5A
RNF123
RRBP1
RUBCN
SECISBP2
SF3B1
SIL1
SMAD2
SMAD3
SMAD4
SMG1
SNRNP70
SPTBN1
STAG1
SVEP1
TBCD
TERF1
TINAGL1
TOB1
TRIM29
TRIP12
TTC37
TWNK
UBA6
UBE3A
UBQLN1
UBQLN4
UNC45A
VCPIP1
VPS8
XAB2
YWHAQ
ZEB2
ZNF484
ZNF557
ZNF587
ZNF587B
ZNF592
ZNF83
ZSCAN4
19 interacting genes:
APP
CDC7
CNOT7
CORO7
DTL
ERBB2
MAPK1
MAPK9
MARCKS
PABPC1
SCMH1
SETDB1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
SMAD6
SMAD9
Entrez ID
4093
10140
HPRD ID
04484
09273
Ensembl ID
ENSG00000120693
ENSG00000141232
Uniprot IDs
A0A024RDR3
O15198
P50616
PDB IDs
6FZT
2D5R
2Z15
5CI8
5CI9
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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