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TSC2 and RABEP1
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
TSC2
RABEP1
Description
TSC complex subunit 2
rabaptin, RAB GTPase binding effector protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Endosome
Early Endosome
Endocytic Vesicle
Early Endosome Membrane
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Recycling Endosome
Molecular Function
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
GTPase Activator Activity
Protein Binding
Growth Factor Activity
Protein Domain Specific Binding
Protein Homodimerization Activity
Biological Process
Neural Tube Closure
Negative Regulation Of Protein Kinase Activity
Protein Import Into Nucleus
Endocytosis
Heart Development
Protein Localization
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of TOR Signaling
Anoikis
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitophagy
Golgi To Plasma Membrane Transport
Endocytosis
Apoptotic Process
Signal Transduction
Protein Transport
Vesicle-mediated Transport
Positive Regulation Of GTPase Activity
Membrane Fusion
Protein Localization To Ciliary Membrane
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
TBC/RABGAPs
Drugs
Diseases
Lymphangioleiomyomatosis (LAM)
Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Body mass index (
28892062
25673413
)
Lymphocyte counts (
32888494
)
Mean platelet volume (
32888494
)
Monocyte count (
32888494
)
Red blood cell density in sickle cell anemia (
28552477
)
White blood cell count (
27863252
)
Interacting Genes
44 interacting genes:
AKT1
AKT2
AKT3
CALM1
CBY2
CCND1
CDKN1B
ESR1
FBXL6
FBXW5
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
NEK1
PAM
PIN1
PLK2
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPS6KA1
SFN
SMAD2
SMAD3
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
58 interacting genes:
ABI2
AIMP2
AP1G1
AP1G2
ATXN7
BARD1
CASP3
CCDC120
CCND1
CDC73
CDK18
CDKL3
CEP57
CFAP53
ELOA
ESCO2
FAM50B
FAM90A1
GAP43
GGA1
GGA2
GGA3
HUNK
ITSN1
LENG1
MAT2B
MCRS1
ODAD3
PELI2
PKP2
PRPF3
RAB1A
RAB33B
RAB4A
RAB4B
RAB5A
RABGEF1
RGS17
RNF39
SMURF1
SNAPIN
SNW1
SRPK2
STAR
TNS4
TRAPPC2L
TRIM26
TSC2
TSHZ2
UBC
UBTFL1
USP2
UTP14C
WASHC3
YWHAG
ZNF438
ZNF512B
ZNF774
Entrez ID
7249
9135
HPRD ID
01850
04684
Ensembl ID
ENSG00000103197
ENSG00000029725
Uniprot IDs
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D7Q2
B4DMM4
Q15276
PDB IDs
1P4U
1TU3
1X79
4N3Y
4N3Z
4Q9U
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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