Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
UBE2I and HSF2BP
Data Source:
BioGRID
(enzymatic study)
UBE2I
HSF2BP
Description
ubiquitin conjugating enzyme E2 I
heat shock transcription factor 2 binding protein
Image
No pdb structure
GO Annotations
Cellular Component
Synaptonemal Complex
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Transferase Complex
Sumoylated E2 Ligase Complex
Chromosome
Cytosol
Molecular Function
Transcription Coregulator Binding
RNA Binding
Protein Binding
ATP Binding
Transcription Factor Binding
SUMO Transferase Activity
Enzyme Binding
Small Protein Activating Enzyme Binding
SUMO Conjugating Enzyme Activity
RING-like Zinc Finger Domain Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Chromosome Segregation
Viral Process
Protein Sumoylation
Negative Regulation Of Transcription, DNA-templated
Cell Division
Positive Regulation Of SUMO Transferase Activity
Transcription By RNA Polymerase II
Male Meiosis I
Spermatogenesis
Double-strand Break Repair Involved In Meiotic Recombination
Pathways
Meiotic synapsis
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
Drugs
Diseases
GWAS
Idiopathic dilated cardiomyopathy (
29495422
)
Monocyte percentage of white cells (
32888494
)
Pulse pressure (
30224653
30578418
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
White blood cell count (
32888494
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Coronary artery disease (
29212778
)
Eosinophil counts (
32888494
)
Eosinophilic esophagitis (
25017104
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Plasma anti-thyroid peroxidase levels (
29678681
)
Pursuit maintenance gain (
29064472
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
Interacting Genes
471 interacting genes:
ACTB
ADAR
ADARB1
ADD3
AGR2
AGTRAP
AKAP17A
ANAPC4
ANXA1
APEX1
APP
AR
ARHGDIA
ARL13B
ARL6IP1
ARNT
ARNTL
ATF2
ATF3
ATF7IP
ATXN1
AURKA
AURKB
BANP
BCAM
BCL11A
BCL2L1
BEND5
BHLHE40
BIRC3
BIRC7
BLM
BLMH
BMI1
BTBD3
C18orf25
CALU
CAMK2D
CAMK2G
CAMSAP2
CARD9
CARM1
CASP2
CASP8AP2
CBLC
CBS
CBSL
CBX4
CCDC6
CD2AP
CDC37
CDCA8
CDH4
CDKN1B
CDR2L
CEBPD
CEBPE
CENPX
CFL2
CFTR
CHD3
CHD4
CHFR
CHMP1A
CHMP4B
CHUK
CLDN2
CLK2
COG1
CORO2A
CREB1
CREBBP
CREBL2
CREM
CSGALNACT2
CSK
CSNK2B
CTBP2
CTNNA1
CYP4F2
DACH1
DAXX
DCTD
DDX21
DDX24
DDX39A
DDX39B
DDX5
DES
DHX9
DMC1
DNM1
DNMT3A
DNMT3B
DPPA2
DPYSL2
DRG1
DTX3L
DZIP3
EDARADD
EDF1
EGR2
EIF2AK2
EIF2B1
ELK1
EP300
ERCC6
ESR1
ETS1
ETV1
ETV6
EXO1
EXOSC9
FADD
FAF1
FAM118A
FANCM
FAS
FATE1
FHIT
FHL3
FLI1
FMR1
FOS
FOXL2
FOXM1
GCM1
GIPC2
GLUL
GMCL1
GMCL2
GMEB1
GMEB2
GOLGA1
GOLGA2
GOLGB1
GRIP1
GTF2I
H4-16
HABP4
HDAC1
HDAC4
HDAC5
HDAC7
HGS
HIC1
HIF1A
HIPK1
HIPK2
HIPK3
HIRA
HMBOX1
HMGB1
HMGN2
HMGXB4
HNF4A
HNRNPC
HNRNPCL1
HNRNPD
HNRNPK
HNRNPLL
HNRNPM
HNRNPU
HSF1
HSF2
HSF2BP
IKBKG
IKZF1
IKZF3
IKZF5
IMPDH1
IPO13
IQGAP1
JUN
JUNB
KAT2A
KAT6B
KCNA5
KCNK1
KCTD1
KDM1A
KHSRP
KLF3
KLF5
KLHL12
KLHL2
KMT5A
KRT19
KRTAP5-2
KRTAP5-4
KRTAP5-9
KTN1
LATS1
LCE1D
LCE1F
LCE2C
LCE3B
LCE5A
LMNA
LMNB1
LMO2
LNX2
LONRF1
LRSAM1
MALL
MAP2K1
MAP3K1
MAPK1IP1L
MARCHF5
MAT2A
MATR3
MDM2
MECOM
MED7
MEF2C
MGRN1
MIPOL1
MITF
MKRN3
MLX
MRTFA
MTA1
MYB
MYBBP1A
MYH9
NACC1
NAF1
NAT10
NCOR2
NFKBIA
NIN
NMI
NOL6
NONO
NOP2
NOP56
NOP58
NOX5
NR1D2
NR1H2
NR1H3
NR1I2
NR3C1
NR3C2
NR5A1
NR5A2
NSD3
NUDCD3
NVL
PAICS
PARK7
PARP1
PAX5
PDLIM7
PDZK1
PELI1
PEX10
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PIM1
PLAAT4
PLAGL1
PML
POLR1H
POU1F1
POU2F1
PPARA
PPARG
PPARGC1A
PPCDC
PPM1J
PRKAA2
PRKDC
PROP1
PRPF40A
PRPF8
PRPSAP1
PSMC3
PSMC6
PSME3
PTEN
PUF60
RABAC1
RAD18
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RB1
RBBP5
RBBP6
RBM14
RBM25
RC3H2
RCBTB2
RFPL3
RHOXF2
RIPK2
RNF10
RNF111
RNF115
RNF128
RNF133
RNF144B
RNF151
RNF185
RNF4
RNF40
RORB
RPL11
RPL7
RPL8
RPRD1B
RPS3A
RPS6KA6
RUSF1
RWDD3
RXRA
SAE1
SALL1
SART1
SATB1
SCNN1A
SEMA6A
SEPTIN1
SETBP1
SETDB1
SETX
SFPQ
SH3KBP1
SIAH1
SIAH2
SIRT1
SKIL
SLC2A1
SLC2A4
SLX4
SMAD4
SNAI2
SND1
SNIP1
SNRNP200
SOCS6
SOX10
SOX4
SOX5
SOX6
SOX9
SP100
SP3
SPECC1L
SPOP
SREBF1
SREBF2
SRF
SRSF4
SSRP1
STAT1
STMN2
STX1A
STX1B
STX2
SUMO1
SUMO1P1
SUMO2
SUMO3
SUPT7L
SUZ12
SYMPK
TAB2
TAF1
TAF10
TAF12
TAF5
TBL1X
TBL1XR1
TBP
TCERG1
TCF3
TCF4
TDG
TDP2
TERF2
TFAP2A
TFAP2B
TFAP2C
TFCP2
TFG
THAP1
THRA
THRB
TIGD3
TLK2
TNFRSF1A
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP63
TP73
TRAF2
TRAF3
TRAF4
TRAF6
TRIM21
TRIM23
TRIM24
TRIM27
TRIM28
TRIM29
TRIM3
TRIM38
TRIM41
TRIM54
TRIM63
TRIM72
TRIP13
TRPS1
TSHZ2
TSN
TSNAX
TTN
TXLNB
UBA2
UBE2K
UBQLN1
UBQLN2
UBXN1
UCHL1
UNC119
USP25
VENTX
VEZF1
VHL
WNK1
WT1
WWP2
XBP1
XIAP
XRCC1
XRCC5
ZBED1
ZBTB1
ZBTB16
ZBTB2
ZBTB26
ZBTB7A
ZBTB8A
ZBTB9
ZC3H10
ZCCHC12
ZCCHC7
ZEB2
ZG16
ZIC1
ZMYM2
ZNF106
ZNF24
ZNF408
ZNF446
ZNF451
ZNF618
ZNF646
ZNF837
ZNRD2
293 interacting genes:
ABI2
ABLIM1
ACTN3
ADD1
ANAPC16
ANKRD55
ANKS1B
ARHGAP45
ARHGEF3
ARHGEF4
ARHGEF5
ARHGEF6
ATXN7L2
BARD1
BAX
BAZ2B
BCAS2
BEND7
BEX2
BLK
BMI1
BYSL
C10orf88
C18orf54
C1orf35
C1orf94
C2CD6
C4orf46
C5orf49
C7orf31
C9orf24
CAMSAP3
CARD9
CASS4
CBX8
CBY2
CCDC113
CCDC116
CCDC120
CCDC13
CCDC130
CCDC146
CCDC185
CCDC187
CCDC198
CCDC33
CCHCR1
CCSER1
CDC37
CDC73
CDCA7L
CDR2L
CDYL2
CEP55
CEP57
CKS1B
CLIP4
CNNM1
CNNM3
CNOT2
COIL
CTSZ
CTTNBP2
CTTNBP2NL
CWF19L2
DALRD3
DCDC2B
DEFB112
DMAP1
DMRT3
DOCK8
DPF2
DUSP13
EAF1
EIF3D
ELOA2
EMD
ENKD1
EPHB3
EPM2AIP1
FAM107A
FAM110A
FAM110B
FAM124B
FAM161B
FAM214B
FAM228A
FAM90A1
FBXO44
FHL2
FHL3
FLYWCH1
FUT9
GAS2L2
GAS8
GCM2
GEM
GGN
GNL3L
GOLGA1
GPANK1
GPATCH2L
GPBP1
GPKOW
GPSM3
H2AW
HASPIN
HCK
HDAC4
HEXIM2
HEY2
HNRNPH2
HOMEZ
HOXB5
HOXC8
HSF2
IER2
IL16
INO80B
INPP5J
INSYN2A
IPMK
IQCC
ITGB3BP
JRK
KANK2
KAT5
KIAA0408
KIF24
KIF5B
KIF9
KIFC3
KLF4
L3MBTL2
L3MBTL3
L3MBTL4
LAGE3
LEP
LGALS4
LMO4
LNX1
LRRC29
LRRC56
LRRN4
LUZP4
MAGED1
MAGOHB
MARCHF7
MEF2A
MFAP1
MISP
MKRN3
MVB12A
MYOZ3
NAB2
NCK2
NFIL3
NHSL2
NME4
NPPA
NSMF
NTAQ1
NUDT10
NXF1
ODF3B
ODF3L2
OPTN
P2RX7
PAK6
PAPSS2
PARD6B
PDLIM7
PICK1
PKD2
PKN1
PKP1
PLB1
PLEKHA2
PLEKHA7
PNMA5
POGZ
POLDIP3
POMC
PPM1K
PPP1R18
PPP1R32
PRPF18
PRPF3
PRPF31
PRR5L
PSMA1
PSTPIP1
RAB11FIP2
RAB36
RAB3IL1
RAD51D
RALY
RBM17
RBM41
RBM48
RCOR3
REXO4
RIBC1
RIN1
RNF135
RNF169
ROBO3
RPS28
RTP5
SAMD4A
SAPCD1
SART1
SAXO1
SCNM1
SDCBP
SELENOV
SEMA3B
SEMA4C
SEPTIN1
SEPTIN9
SETDB1
SH2D4A
SHFL
SHISA6
SIRPA
SLAIN1
SLC6A1
SMARCB1
SMARCD1
SMG9
SNAPC1
SNW1
SNX18
SNX21
SPATA22
SPEG
SPG7
SPRED1
SPRY1
SYCE1L
SYNGAP1
TAB2
TAGAP
TASOR2
TBC1D1
TBC1D30
TCEA2
TCF19
TEPSIN
TFIP11
THAP6
TMEFF2
TMSB4X
TNS4
TOX2
TP53BP2
TRAF5
TRARG1
TSEN15
TSGA10IP
TSHZ3
TTC23
TTC9C
TULP3
UBE2I
UPF2
UPRT
USP20
VEZF1
VHL
VPS72
WASF1
WASHC1
WDR25
ZBTB16
ZBTB42
ZC2HC1C
ZCWPW2
ZFC3H1
ZGPAT
ZNF185
ZNF250
ZNF417
ZNF511
ZNF564
ZNF581
ZNF587
ZNF648
ZNF688
ZNF774
ZNF835
ZNF84
ZNF844
Entrez ID
7329
11077
HPRD ID
09045
05186
Ensembl ID
ENSG00000103275
ENSG00000160207
Uniprot IDs
A8K503
B0QYN7
P63279
O75031
Q6IAT7
PDB IDs
1A3S
1KPS
1Z5Q
1Z5S
2GRN
2GRO
2GRP
2GRQ
2GRR
2O25
2PE6
2PX9
2XWU
3A4S
3UIN
3UIO
3UIP
4W5V
4Y1L
5D2M
5F6D
5F6E
5F6U
5F6V
5F6W
5F6X
5F6Y
5FQ2
6SYF
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?