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UBE2I and PTEN
Data Source:
HPRD
(in vitro)
UBE2I
PTEN
Description
ubiquitin conjugating enzyme E2 I
phosphatase and tensin homolog
Image
GO Annotations
Cellular Component
Synaptonemal Complex
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Transferase Complex
Sumoylated E2 Ligase Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Apical Plasma Membrane
PML Body
Myelin Sheath Adaxonal Region
Cell Projection
Neuron Projection
Dendritic Spine
Schmidt-Lanterman Incisure
Postsynaptic Membrane
Postsynaptic Cytosol
Molecular Function
Transcription Coregulator Binding
RNA Binding
Protein Binding
ATP Binding
Transcription Factor Binding
SUMO Transferase Activity
Enzyme Binding
Small Protein Activating Enzyme Binding
SUMO Conjugating Enzyme Activity
RING-like Zinc Finger Domain Binding
Phosphatidylinositol-3-phosphatase Activity
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Lipid Binding
Anaphase-promoting Complex Binding
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity
Enzyme Binding
PDZ Domain Binding
Ionotropic Glutamate Receptor Binding
Identical Protein Binding
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Ubiquitin-specific Protease Binding
Protein Tyrosine Kinase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Chromosome Segregation
Viral Process
Protein Sumoylation
Negative Regulation Of Transcription, DNA-templated
Cell Division
Positive Regulation Of SUMO Transferase Activity
Angiogenesis
Negative Regulation Of Protein Phosphorylation
Regulation Of B Cell Apoptotic Process
Transcription Initiation From RNA Polymerase II Promoter
Protein Dephosphorylation
Phosphatidylinositol Biosynthetic Process
Apoptotic Process
Neuron-neuron Synaptic Transmission
Synapse Assembly
Central Nervous System Development
Heart Development
Aging
Response To Nutrient
Learning Or Memory
Memory
Locomotory Behavior
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Glucose
Response To Zinc Ion
Positive Regulation Of Gene Expression
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Neuron Projection Development
Negative Regulation Of Neuron Projection Development
Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Activity
Dephosphorylation
Cell Migration
Protein Deubiquitination
Dentate Gyrus Development
Central Nervous System Neuron Axonogenesis
Negative Regulation Of Cell Migration
Adult Behavior
Negative Regulation Of Myelination
Regulation Of Protein Stability
Regulation Of Synaptic Transmission, GABAergic
Central Nervous System Myelin Maintenance
Response To Estradiol
Regulation Of Cellular Component Size
Cellular Response To Insulin Stimulus
Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of Peptidyl-serine Phosphorylation
Response To ATP
Multicellular Organismal Response To Stress
Social Behavior
Peptidyl-tyrosine Dephosphorylation
Response To Drug
Maternal Behavior
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Endothelial Cell Migration
Inositol Phosphate Metabolic Process
Cellular Response To Leptin Stimulus
Locomotor Rhythm
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Size
Negative Regulation Of Organ Growth
Response To Arsenic-containing Substance
Inositol Phosphate Dephosphorylation
Phosphatidylinositol Dephosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Negative Regulation Of Axon Regeneration
Cardiac Muscle Tissue Development
Forebrain Morphogenesis
Brain Morphogenesis
Cell Motility
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Phagocytosis
Negative Regulation Of Axonogenesis
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Keratinocyte Migration
Negative Regulation Of Focal Adhesion Assembly
Regulation Of Protein Kinase B Signaling
Negative Regulation Of Protein Kinase B Signaling
Rhythmic Synaptic Transmission
Negative Regulation Of Cardiac Muscle Cell Proliferation
Canonical Wnt Signaling Pathway
Synapse Maturation
Prepulse Inhibition
Male Mating Behavior
Long-term Synaptic Potentiation
Long-term Synaptic Depression
Prostate Gland Growth
Dendritic Spine Morphogenesis
Negative Regulation Of Dendritic Spine Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Electrical Stimulus
Cellular Response To Ethanol
Cellular Response To Hypoxia
Negative Regulation Of Ribosome Biogenesis
Negative Regulation Of Cell Aging
Negative Regulation Of Excitatory Postsynaptic Potential
Presynaptic Membrane Assembly
Postsynaptic Density Assembly
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells
Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Ubiquitin Protein Ligase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Signaling Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Negative Regulation Of Synaptic Vesicle Clustering
Pathways
Meiotic synapsis
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Negative regulation of the PI3K/AKT network
Downstream TCR signaling
TP53 Regulates Metabolic Genes
PTEN Loss of Function in Cancer
Ub-specific processing proteases
Ovarian tumor domain proteases
Regulation of PTEN mRNA translation
Regulation of PTEN localization
Regulation of PTEN stability and activity
Transcriptional Regulation by MECP2
Drugs
Phosphatidylethanolamine
Diseases
Vulvar cancer
Prostate cancer
Endometrial Cancer
Glioma
Small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Malignant melanoma
GWAS
Idiopathic dilated cardiomyopathy (
29495422
)
Monocyte percentage of white cells (
32888494
)
Pulse pressure (
30224653
30578418
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
White blood cell count (
32888494
)
Ambidextrousness (
32989287
)
Birth weight (
31043758
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Height (
31562340
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Mercury levels (
26025379
)
Multiple sclerosis (
31604244
)
Neutrophil count (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
)
Periodontitis (Mean PAL) (
24024966
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Psoriasis (
28537254
)
Pulse pressure (
27841878
)
Red blood cell count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Type 2 diabetes (
24509480
32499647
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
White blood cell count (
32888494
)
White blood cell count (basophil) (
29403010
)
Interacting Genes
471 interacting genes:
ACTB
ADAR
ADARB1
ADD3
AGR2
AGTRAP
AKAP17A
ANAPC4
ANXA1
APEX1
APP
AR
ARHGDIA
ARL13B
ARL6IP1
ARNT
ARNTL
ATF2
ATF3
ATF7IP
ATXN1
AURKA
AURKB
BANP
BCAM
BCL11A
BCL2L1
BEND5
BHLHE40
BIRC3
BIRC7
BLM
BLMH
BMI1
BTBD3
C18orf25
CALU
CAMK2D
CAMK2G
CAMSAP2
CARD9
CARM1
CASP2
CASP8AP2
CBLC
CBS
CBSL
CBX4
CCDC6
CD2AP
CDC37
CDCA8
CDH4
CDKN1B
CDR2L
CEBPD
CEBPE
CENPX
CFL2
CFTR
CHD3
CHD4
CHFR
CHMP1A
CHMP4B
CHUK
CLDN2
CLK2
COG1
CORO2A
CREB1
CREBBP
CREBL2
CREM
CSGALNACT2
CSK
CSNK2B
CTBP2
CTNNA1
CYP4F2
DACH1
DAXX
DCTD
DDX21
DDX24
DDX39A
DDX39B
DDX5
DES
DHX9
DMC1
DNM1
DNMT3A
DNMT3B
DPPA2
DPYSL2
DRG1
DTX3L
DZIP3
EDARADD
EDF1
EGR2
EIF2AK2
EIF2B1
ELK1
EP300
ERCC6
ESR1
ETS1
ETV1
ETV6
EXO1
EXOSC9
FADD
FAF1
FAM118A
FANCM
FAS
FATE1
FHIT
FHL3
FLI1
FMR1
FOS
FOXL2
FOXM1
GCM1
GIPC2
GLUL
GMCL1
GMCL2
GMEB1
GMEB2
GOLGA1
GOLGA2
GOLGB1
GRIP1
GTF2I
H4-16
HABP4
HDAC1
HDAC4
HDAC5
HDAC7
HGS
HIC1
HIF1A
HIPK1
HIPK2
HIPK3
HIRA
HMBOX1
HMGB1
HMGN2
HMGXB4
HNF4A
HNRNPC
HNRNPCL1
HNRNPD
HNRNPK
HNRNPLL
HNRNPM
HNRNPU
HSF1
HSF2
HSF2BP
IKBKG
IKZF1
IKZF3
IKZF5
IMPDH1
IPO13
IQGAP1
JUN
JUNB
KAT2A
KAT6B
KCNA5
KCNK1
KCTD1
KDM1A
KHSRP
KLF3
KLF5
KLHL12
KLHL2
KMT5A
KRT19
KRTAP5-2
KRTAP5-4
KRTAP5-9
KTN1
LATS1
LCE1D
LCE1F
LCE2C
LCE3B
LCE5A
LMNA
LMNB1
LMO2
LNX2
LONRF1
LRSAM1
MALL
MAP2K1
MAP3K1
MAPK1IP1L
MARCHF5
MAT2A
MATR3
MDM2
MECOM
MED7
MEF2C
MGRN1
MIPOL1
MITF
MKRN3
MLX
MRTFA
MTA1
MYB
MYBBP1A
MYH9
NACC1
NAF1
NAT10
NCOR2
NFKBIA
NIN
NMI
NOL6
NONO
NOP2
NOP56
NOP58
NOX5
NR1D2
NR1H2
NR1H3
NR1I2
NR3C1
NR3C2
NR5A1
NR5A2
NSD3
NUDCD3
NVL
PAICS
PARK7
PARP1
PAX5
PDLIM7
PDZK1
PELI1
PEX10
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PIM1
PLAAT4
PLAGL1
PML
POLR1H
POU1F1
POU2F1
PPARA
PPARG
PPARGC1A
PPCDC
PPM1J
PRKAA2
PRKDC
PROP1
PRPF40A
PRPF8
PRPSAP1
PSMC3
PSMC6
PSME3
PTEN
PUF60
RABAC1
RAD18
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RB1
RBBP5
RBBP6
RBM14
RBM25
RC3H2
RCBTB2
RFPL3
RHOXF2
RIPK2
RNF10
RNF111
RNF115
RNF128
RNF133
RNF144B
RNF151
RNF185
RNF4
RNF40
RORB
RPL11
RPL7
RPL8
RPRD1B
RPS3A
RPS6KA6
RUSF1
RWDD3
RXRA
SAE1
SALL1
SART1
SATB1
SCNN1A
SEMA6A
SEPTIN1
SETBP1
SETDB1
SETX
SFPQ
SH3KBP1
SIAH1
SIAH2
SIRT1
SKIL
SLC2A1
SLC2A4
SLX4
SMAD4
SNAI2
SND1
SNIP1
SNRNP200
SOCS6
SOX10
SOX4
SOX5
SOX6
SOX9
SP100
SP3
SPECC1L
SPOP
SREBF1
SREBF2
SRF
SRSF4
SSRP1
STAT1
STMN2
STX1A
STX1B
STX2
SUMO1
SUMO1P1
SUMO2
SUMO3
SUPT7L
SUZ12
SYMPK
TAB2
TAF1
TAF10
TAF12
TAF5
TBL1X
TBL1XR1
TBP
TCERG1
TCF3
TCF4
TDG
TDP2
TERF2
TFAP2A
TFAP2B
TFAP2C
TFCP2
TFG
THAP1
THRA
THRB
TIGD3
TLK2
TNFRSF1A
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP63
TP73
TRAF2
TRAF3
TRAF4
TRAF6
TRIM21
TRIM23
TRIM24
TRIM27
TRIM28
TRIM29
TRIM3
TRIM38
TRIM41
TRIM54
TRIM63
TRIM72
TRIP13
TRPS1
TSHZ2
TSN
TSNAX
TTN
TXLNB
UBA2
UBE2K
UBQLN1
UBQLN2
UBXN1
UCHL1
UNC119
USP25
VENTX
VEZF1
VHL
WNK1
WT1
WWP2
XBP1
XIAP
XRCC1
XRCC5
ZBED1
ZBTB1
ZBTB16
ZBTB2
ZBTB26
ZBTB7A
ZBTB8A
ZBTB9
ZC3H10
ZCCHC12
ZCCHC7
ZEB2
ZG16
ZIC1
ZMYM2
ZNF106
ZNF24
ZNF408
ZNF446
ZNF451
ZNF618
ZNF646
ZNF837
ZNRD2
356 interacting genes:
AATK
ABCF2
ACTL6A
ADAR
AFP
AKAP12
AKT1
ALYREF
AMOT
ANAPC10
ANAPC7
ANG
ANP32B
ANP32E
ANXA2
AR
ARF4
ARMCX3
ASCC3
ATP5F1A
ATP5F1C
BCAR1
BEX1
BUB3
CAD
CALM1
CAMK2G
CAV1
CCDC180
CCDC47
CCND2
CCT2
CCT3
CCT4
CCT6A
CCT8
CDC27
CEP170
CEP97
CFL1
CHD4
CHGB
CMAS
COPA
COPB1
COPS6
CSNK1A1
CSNK2A1
CSNK2A2
CUL4B
CXCL1
DAP3
DAXX
DBN1
DCAF11
DCAF13
DDB1
DDOST
DDX1
DDX21
DDX24
DDX47
DDX50
DHX15
DHX9
DLC1
DLG1
DNAJA1
DNAJA2
DNAJA3
DNAJB6
DNAJC10
DPM1
DRG1
DSP
EEF2
EIF4E
EIF6
EPHA2
EPRS1
ERBB3
ESR1
EXOSC1
EXOSC2
EXOSC4
EXOSC5
EXOSC7
FARSA
FARSB
FASN
FBL
FBXW11
FOXK1
FUBP3
GEMIN4
GNAI1
GNAI2
GNB4
GNL3
GPC4
GSTM2
GTF3C2
GTF3C3
GTF3C5
H2AC4
HADHA
HBA1
HNRNPA1
HNRNPA3
HNRNPAB
HNRNPUL1
HSD17B1
HSD17B10
HSP90AB1
HSP90B1
HSPA4
HSPA4L
HSPA8
HSPBP1
HSPD1
HSPH1
IL24
ILF2
ILF3
INS
IPO5
IPO7
IRS4
ITPRID2
JUP
KBTBD4
KDM1A
KPNB1
LATS1
LGALS1
LIMA1
LINC00839
LINC01198
LINC02023
LMNB1
LRPPRC
LTV1
MAGED2
MAGI2
MAGI3
MAP2K3
MAST1
MAST2
MAST3
MATR3
MCM2
MCM3
MCM5
MCRS1
MDN1
METTL26
MKI67
MME
MPRIP
MRPS22
MRPS23
MRPS27
MRPS28
MRPS7
MRPS9
MSH6
MTHFD2
MVP
MYBBP1A
MYC
MYH10
MYL12A
MYO1B
MYO1C
MYO1D
MYOF
NACA
NCBP1
NCF1
NDFIP1
NGB
NOP56
NOP58
NPM3
NUMB
OSGIN1
OTUD3
PBK
PBRM1
PCNA
PDGFRB
PELO
PELP1
PHB
PHB2
PKM
PLEC
PLK1
POLDIP2
POLR1A
POLR2A
POLR2B
POLR2H
POP1
PPL
PPP1CA
PPP2CA
PRDX1
PRDX3
PRKDC
PRPF19
PRPF8
PSMD3
PSMD4
PSMD7
PTDSS1
PTK2
PTK7
PURA
PXN
QPCTL
RAD21
RANBP2
RANGAP1
RBBP5
RBM4
RCC2
RCN1
RFC3
RFC4
RFC5
RING1
RPL10
RPL10A
RPL12
RPL13
RPL13A
RPL14
RPL17
RPL18A
RPL21
RPL22
RPL22L1
RPL23
RPL23A
RPL27
RPL27A
RPL28
RPL30
RPL31
RPL32
RPL34
RPL36
RPL38
RPL7
RPLP0
RPLP2
RPN2
RPP30
RPP38
RPP40
RPS11
RPS13
RPS15
RPS15A
RPS17
RPS2
RPS20
RPS23
RPS25
RPS26
RPS27
RPS27A
RPS3
RPS4X
RPS5
RPS6
RPS9
RSL1D1
S100A8
S100A9
SDC1
SDC4
SDCBP
SEC61A1
SET
SETX
SIN3A
SIRT4
SKP1
SLC25A1
SLC25A13
SLC25A3
SLC25A5
SLC9A3R1
SLC9A3R2
SMARCA4
SMARCA5
SMC2
SMC4
SMCHD1
SNAI1
SNRNP200
SNRPA1
SNRPB2
SNRPD1
SNTB2
SNX27
SPTAN1
SPTBN1
SRP14
SSB
SSR4
SSRP1
STAG2
STK11
STRAP
STUB1
SUDS3
SUGP2
TCF25
TCP1
TECR
TERF2IP
THOC2
THOC3
THOC6
TMEFF1
TNKS
TNKS2
TP53
TRIM28
TRMO
TUBA1B
TUBB
TUBB4B
TUFM
TWIST1
TXN
U2AF1
UBE2D3
UBE2I
UBE2L3
UBE2S
UPF1
USP7
USP9X
UTP14A
UTRN
XRCC5
XRCC6
YAP1
YES1
YTHDC2
YTHDF2
ZNF326
Entrez ID
7329
5728
HPRD ID
09045
03431
Ensembl ID
ENSG00000103275
ENSG00000171862
Uniprot IDs
A8K503
B0QYN7
P63279
F6KD01
P60484
PDB IDs
1A3S
1KPS
1Z5Q
1Z5S
2GRN
2GRO
2GRP
2GRQ
2GRR
2O25
2PE6
2PX9
2XWU
3A4S
3UIN
3UIO
3UIP
4W5V
4Y1L
5D2M
5F6D
5F6E
5F6U
5F6V
5F6W
5F6X
5F6Y
5FQ2
6SYF
1D5R
2KYL
4O1V
5BUG
5BZX
5BZZ
Enriched GO Terms of Interacting Partners
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