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HSF2BP and VHL
Data Source:
BioGRID
(two hybrid)
HSF2BP
VHL
Description
heat shock transcription factor 2 binding protein
von Hippel-Lindau tumor suppressor
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome
Cytosol
Nucleus
Nucleoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Membrane
Molecular Function
Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Ubiquitin Ligase-substrate Adaptor Activity
Biological Process
Transcription By RNA Polymerase II
Male Meiosis I
Spermatogenesis
Double-strand Break Repair Involved In Meiotic Recombination
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Regulation Of Transcription, DNA-templated
Proteolysis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Post-translational Protein Modification
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Stabilization
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMOylation of ubiquitinylation proteins
Neddylation
Replication of the SARS-CoV-1 genome
Replication of the SARS-CoV-2 genome
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Renal cell carcinoma
von Hippel-Lindau syndrome
Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Coronary artery disease (
29212778
)
Eosinophil counts (
32888494
)
Eosinophilic esophagitis (
25017104
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Plasma anti-thyroid peroxidase levels (
29678681
)
Pursuit maintenance gain (
29064472
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
Interacting Genes
293 interacting genes:
ABI2
ABLIM1
ACTN3
ADD1
ANAPC16
ANKRD55
ANKS1B
ARHGAP45
ARHGEF3
ARHGEF4
ARHGEF5
ARHGEF6
ATXN7L2
BARD1
BAX
BAZ2B
BCAS2
BEND7
BEX2
BLK
BMI1
BYSL
C10orf88
C18orf54
C1orf35
C1orf94
C2CD6
C4orf46
C5orf49
C7orf31
C9orf24
CAMSAP3
CARD9
CASS4
CBX8
CBY2
CCDC113
CCDC116
CCDC120
CCDC13
CCDC130
CCDC146
CCDC185
CCDC187
CCDC198
CCDC33
CCHCR1
CCSER1
CDC37
CDC73
CDCA7L
CDR2L
CDYL2
CEP55
CEP57
CKS1B
CLIP4
CNNM1
CNNM3
CNOT2
COIL
CTSZ
CTTNBP2
CTTNBP2NL
CWF19L2
DALRD3
DCDC2B
DEFB112
DMAP1
DMRT3
DOCK8
DPF2
DUSP13
EAF1
EIF3D
ELOA2
EMD
ENKD1
EPHB3
EPM2AIP1
FAM107A
FAM110A
FAM110B
FAM124B
FAM161B
FAM214B
FAM228A
FAM90A1
FBXO44
FHL2
FHL3
FLYWCH1
FUT9
GAS2L2
GAS8
GCM2
GEM
GGN
GNL3L
GOLGA1
GPANK1
GPATCH2L
GPBP1
GPKOW
GPSM3
H2AW
HASPIN
HCK
HDAC4
HEXIM2
HEY2
HNRNPH2
HOMEZ
HOXB5
HOXC8
HSF2
IER2
IL16
INO80B
INPP5J
INSYN2A
IPMK
IQCC
ITGB3BP
JRK
KANK2
KAT5
KIAA0408
KIF24
KIF5B
KIF9
KIFC3
KLF4
L3MBTL2
L3MBTL3
L3MBTL4
LAGE3
LEP
LGALS4
LMO4
LNX1
LRRC29
LRRC56
LRRN4
LUZP4
MAGED1
MAGOHB
MARCHF7
MEF2A
MFAP1
MISP
MKRN3
MVB12A
MYOZ3
NAB2
NCK2
NFIL3
NHSL2
NME4
NPPA
NSMF
NTAQ1
NUDT10
NXF1
ODF3B
ODF3L2
OPTN
P2RX7
PAK6
PAPSS2
PARD6B
PDLIM7
PICK1
PKD2
PKN1
PKP1
PLB1
PLEKHA2
PLEKHA7
PNMA5
POGZ
POLDIP3
POMC
PPM1K
PPP1R18
PPP1R32
PRPF18
PRPF3
PRPF31
PRR5L
PSMA1
PSTPIP1
RAB11FIP2
RAB36
RAB3IL1
RAD51D
RALY
RBM17
RBM41
RBM48
RCOR3
REXO4
RIBC1
RIN1
RNF135
RNF169
ROBO3
RPS28
RTP5
SAMD4A
SAPCD1
SART1
SAXO1
SCNM1
SDCBP
SELENOV
SEMA3B
SEMA4C
SEPTIN1
SEPTIN9
SETDB1
SH2D4A
SHFL
SHISA6
SIRPA
SLAIN1
SLC6A1
SMARCB1
SMARCD1
SMG9
SNAPC1
SNW1
SNX18
SNX21
SPATA22
SPEG
SPG7
SPRED1
SPRY1
SYCE1L
SYNGAP1
TAB2
TAGAP
TASOR2
TBC1D1
TBC1D30
TCEA2
TCF19
TEPSIN
TFIP11
THAP6
TMEFF2
TMSB4X
TNS4
TOX2
TP53BP2
TRAF5
TRARG1
TSEN15
TSGA10IP
TSHZ3
TTC23
TTC9C
TULP3
UBE2I
UPF2
UPRT
USP20
VEZF1
VHL
VPS72
WASF1
WASHC1
WDR25
ZBTB16
ZBTB42
ZC2HC1C
ZCWPW2
ZFC3H1
ZGPAT
ZNF185
ZNF250
ZNF417
ZNF511
ZNF564
ZNF581
ZNF587
ZNF648
ZNF688
ZNF774
ZNF835
ZNF84
ZNF844
107 interacting genes:
ACTB
AKT1
APP
AR
AURKA
CAPN7
CAPZB
CASR
CBR1
CBX1
CBX3
CCNC
CCT3
CD44
CDC34
CDKN2A
CERKL
CHEK2
CLU
COL4A2
CSNK2A1
CUL2
CUL5
DGKI
DNAJA3
DVL2
E2F1
EEF1B2
EGLN1
ELOB
ELOC
EPAS1
EPOR
FKBP8
FLNA
FN1
GHET1
GPS1
H1-2
H2BC13
H4-16
HDAC1
HDAC2
HDAC3
HIF1A
HIF1AN
HIF3A
HNRNPA2B1
HNRNPD
HSF2BP
HSPA5
HSPA8
IKBKB
JADE1
KIF2C
KIF3A
KLF4
LANCL1
MAP1LC3B
MDFI
NCL
NR4A1
NR4A2
NR4A3
PDCD5
PIAS4
PLD1
PLD2
POLR2G
PPP5C
PRDX1
PRKCI
PRMT1
PRMT8
PSMC3
RB1CC1
RBPMS
RBPMS2
RBX1
RHOBTB3
RNF139
RPL21
RPL5
RPS15A
RWDD3
SARNP
SAT2
SKP2
SLC2A1
SLC3A2
SON
SP1
TPT1
TRIM28
UBE2D1
UBE2D2
UBE2I
UBE2S
USP20
USP33
USP9X
UXT
VAPB
VBP1
YY1AP1
ZNF197
ZNF512B
Entrez ID
11077
7428
HPRD ID
05186
01905
Ensembl ID
ENSG00000160207
ENSG00000134086
Uniprot IDs
O75031
Q6IAT7
A0A024R2F2
A0A0S2Z4K1
P40337
PDB IDs
1LM8
1LQB
1VCB
3ZRC
3ZRF
3ZTC
3ZTD
3ZUN
4AJY
4AWJ
4B95
4B9K
4BKS
4BKT
4W9C
4W9D
4W9E
4W9F
4W9G
4W9H
4W9I
4W9J
4W9K
4W9L
4WQO
5LLI
5N4W
5NVV
5NVW
5NVX
5NVY
5NVZ
5NW0
5NW1
5NW2
5T35
6BVB
6FMI
6FMJ
6FMK
6GFX
6GFY
6GFZ
6GMN
6GMQ
6GMR
6GMX
6HAX
6HAY
6HR2
6I7Q
6I7R
6R6H
6R7F
6SIS
6ZHC
Enriched GO Terms of Interacting Partners
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