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UBE2I and HGS
Data Source:
HPRD
(two hybrid)
UBE2I
HGS
Description
ubiquitin conjugating enzyme E2 I
hepatocyte growth factor-regulated tyrosine kinase substrate
Image
GO Annotations
Cellular Component
Synaptonemal Complex
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Transferase Complex
Sumoylated E2 Ligase Complex
Lysosome
Endosome
Early Endosome
Cytosol
Early Endosome Membrane
Multivesicular Body Membrane
ESCRT-0 Complex
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Transcription Coregulator Binding
RNA Binding
Protein Binding
ATP Binding
Transcription Factor Binding
SUMO Transferase Activity
Enzyme Binding
Small Protein Activating Enzyme Binding
SUMO Conjugating Enzyme Activity
RING-like Zinc Finger Domain Binding
Protein Binding
Protein Domain Specific Binding
Ubiquitin-like Protein Ligase Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Chromosome Segregation
Viral Process
Protein Sumoylation
Negative Regulation Of Transcription, DNA-templated
Cell Division
Positive Regulation Of SUMO Transferase Activity
Protein Targeting To Lysosome
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Membrane Invagination
Positive Regulation Of Gene Expression
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Endosomal Transport
Macroautophagy
Negative Regulation Of Angiogenesis
Protein Deubiquitination
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Multivesicular Body Assembly
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Regulation Of MAP Kinase Activity
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Membrane Organization
Protein Localization To Membrane
Positive Regulation Of Exosomal Secretion
Pathways
Meiotic synapsis
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
EGFR downregulation
Lysosome Vesicle Biogenesis
Ub-specific processing proteases
Negative regulation of MET activity
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
InlB-mediated entry of Listeria monocytogenes into host cell
Endosomal Sorting Complex Required For Transport (ESCRT)
Inhibition of membrane repair
Prevention of phagosomal-lysosomal fusion
RHOBTB3 ATPase cycle
Drugs
Citric acid
Diseases
GWAS
Idiopathic dilated cardiomyopathy (
29495422
)
Monocyte percentage of white cells (
32888494
)
Pulse pressure (
30224653
30578418
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
White blood cell count (
32888494
)
Eye color traits (
20463881
)
Refractive error (
32231278
)
Interacting Genes
471 interacting genes:
ACTB
ADAR
ADARB1
ADD3
AGR2
AGTRAP
AKAP17A
ANAPC4
ANXA1
APEX1
APP
AR
ARHGDIA
ARL13B
ARL6IP1
ARNT
ARNTL
ATF2
ATF3
ATF7IP
ATXN1
AURKA
AURKB
BANP
BCAM
BCL11A
BCL2L1
BEND5
BHLHE40
BIRC3
BIRC7
BLM
BLMH
BMI1
BTBD3
C18orf25
CALU
CAMK2D
CAMK2G
CAMSAP2
CARD9
CARM1
CASP2
CASP8AP2
CBLC
CBS
CBSL
CBX4
CCDC6
CD2AP
CDC37
CDCA8
CDH4
CDKN1B
CDR2L
CEBPD
CEBPE
CENPX
CFL2
CFTR
CHD3
CHD4
CHFR
CHMP1A
CHMP4B
CHUK
CLDN2
CLK2
COG1
CORO2A
CREB1
CREBBP
CREBL2
CREM
CSGALNACT2
CSK
CSNK2B
CTBP2
CTNNA1
CYP4F2
DACH1
DAXX
DCTD
DDX21
DDX24
DDX39A
DDX39B
DDX5
DES
DHX9
DMC1
DNM1
DNMT3A
DNMT3B
DPPA2
DPYSL2
DRG1
DTX3L
DZIP3
EDARADD
EDF1
EGR2
EIF2AK2
EIF2B1
ELK1
EP300
ERCC6
ESR1
ETS1
ETV1
ETV6
EXO1
EXOSC9
FADD
FAF1
FAM118A
FANCM
FAS
FATE1
FHIT
FHL3
FLI1
FMR1
FOS
FOXL2
FOXM1
GCM1
GIPC2
GLUL
GMCL1
GMCL2
GMEB1
GMEB2
GOLGA1
GOLGA2
GOLGB1
GRIP1
GTF2I
H4-16
HABP4
HDAC1
HDAC4
HDAC5
HDAC7
HGS
HIC1
HIF1A
HIPK1
HIPK2
HIPK3
HIRA
HMBOX1
HMGB1
HMGN2
HMGXB4
HNF4A
HNRNPC
HNRNPCL1
HNRNPD
HNRNPK
HNRNPLL
HNRNPM
HNRNPU
HSF1
HSF2
HSF2BP
IKBKG
IKZF1
IKZF3
IKZF5
IMPDH1
IPO13
IQGAP1
JUN
JUNB
KAT2A
KAT6B
KCNA5
KCNK1
KCTD1
KDM1A
KHSRP
KLF3
KLF5
KLHL12
KLHL2
KMT5A
KRT19
KRTAP5-2
KRTAP5-4
KRTAP5-9
KTN1
LATS1
LCE1D
LCE1F
LCE2C
LCE3B
LCE5A
LMNA
LMNB1
LMO2
LNX2
LONRF1
LRSAM1
MALL
MAP2K1
MAP3K1
MAPK1IP1L
MARCHF5
MAT2A
MATR3
MDM2
MECOM
MED7
MEF2C
MGRN1
MIPOL1
MITF
MKRN3
MLX
MRTFA
MTA1
MYB
MYBBP1A
MYH9
NACC1
NAF1
NAT10
NCOR2
NFKBIA
NIN
NMI
NOL6
NONO
NOP2
NOP56
NOP58
NOX5
NR1D2
NR1H2
NR1H3
NR1I2
NR3C1
NR3C2
NR5A1
NR5A2
NSD3
NUDCD3
NVL
PAICS
PARK7
PARP1
PAX5
PDLIM7
PDZK1
PELI1
PEX10
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PIM1
PLAAT4
PLAGL1
PML
POLR1H
POU1F1
POU2F1
PPARA
PPARG
PPARGC1A
PPCDC
PPM1J
PRKAA2
PRKDC
PROP1
PRPF40A
PRPF8
PRPSAP1
PSMC3
PSMC6
PSME3
PTEN
PUF60
RABAC1
RAD18
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RB1
RBBP5
RBBP6
RBM14
RBM25
RC3H2
RCBTB2
RFPL3
RHOXF2
RIPK2
RNF10
RNF111
RNF115
RNF128
RNF133
RNF144B
RNF151
RNF185
RNF4
RNF40
RORB
RPL11
RPL7
RPL8
RPRD1B
RPS3A
RPS6KA6
RUSF1
RWDD3
RXRA
SAE1
SALL1
SART1
SATB1
SCNN1A
SEMA6A
SEPTIN1
SETBP1
SETDB1
SETX
SFPQ
SH3KBP1
SIAH1
SIAH2
SIRT1
SKIL
SLC2A1
SLC2A4
SLX4
SMAD4
SNAI2
SND1
SNIP1
SNRNP200
SOCS6
SOX10
SOX4
SOX5
SOX6
SOX9
SP100
SP3
SPECC1L
SPOP
SREBF1
SREBF2
SRF
SRSF4
SSRP1
STAT1
STMN2
STX1A
STX1B
STX2
SUMO1
SUMO1P1
SUMO2
SUMO3
SUPT7L
SUZ12
SYMPK
TAB2
TAF1
TAF10
TAF12
TAF5
TBL1X
TBL1XR1
TBP
TCERG1
TCF3
TCF4
TDG
TDP2
TERF2
TFAP2A
TFAP2B
TFAP2C
TFCP2
TFG
THAP1
THRA
THRB
TIGD3
TLK2
TNFRSF1A
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP63
TP73
TRAF2
TRAF3
TRAF4
TRAF6
TRIM21
TRIM23
TRIM24
TRIM27
TRIM28
TRIM29
TRIM3
TRIM38
TRIM41
TRIM54
TRIM63
TRIM72
TRIP13
TRPS1
TSHZ2
TSN
TSNAX
TTN
TXLNB
UBA2
UBE2K
UBQLN1
UBQLN2
UBXN1
UCHL1
UNC119
USP25
VENTX
VEZF1
VHL
WNK1
WT1
WWP2
XBP1
XIAP
XRCC1
XRCC5
ZBED1
ZBTB1
ZBTB16
ZBTB2
ZBTB26
ZBTB7A
ZBTB8A
ZBTB9
ZC3H10
ZCCHC12
ZCCHC7
ZEB2
ZG16
ZIC1
ZMYM2
ZNF106
ZNF24
ZNF408
ZNF446
ZNF451
ZNF618
ZNF646
ZNF837
ZNRD2
328 interacting genes:
ABI2
ACLY
ACOT11
ACTN3
ADRA2C
AHCYL1
AKAP8L
ANKRD55
ANTKMT
APC
APLP2
APP
ARFIP2
ARL6IP1
ARMC7
ASB12
ATN1
ATP1A1
ATP2A2
ATXN1L
BBC3
BCAS2
BEGAIN
BFSP2
BICRAL
BLOC1S1
BORCS6
BRINP3
BSG
C11orf1
C1orf94
C20orf173
C3orf36
C9orf24
CASK
CBS
CCDC103
CCDC136
CCDC196
CCDC33
CCND3
CDR2
CDSN
CEACAM6
CEP55
CEP57L1
CEP63
CEP68
CLTC
COG8
CRMP1
CRX
CSNK2A1
CSTF2
CSTF2T
CTTNBP2NL
CYB5R2
DAAM2
DAZAP2
DCTN2
DECR1
DEUP1
DGCR6
DLG4
DNAJC5
DSN1
DTX2
DYDC1
EFHC2
EGFL7
EGFR
EHMT2
EIF3F
EPS15
ESRRG
EXOC3L1
EXOC5
EXOC7
EXOC8
EYA2
FAM166A
FAM168A
FAM185A
FANCG
FBN1
FCHSD2
FIGN
FLOT1
FLOT2
FNDC11
FOXD4L1
FOXI1
FSD2
FTCD
GATC
GFAP
GFI1B
GGA2
GKAP1
GOLGA2
GOLGA6L9
GOLGA7B
GUCA1C
HAP1
HAUS1
HNRNPDL
HNRNPM
HSF4
HSFY1
HSPA8
ICA1L
IFNA16
IFT74
IL2RB
IL4R
ILKAP
ING5
INTS4
IPO4
JAKMIP2
JMJD7
KIAA0753
KIAA0825
KLF4
KRT13
KRT14
KRT15
KRT16
KRT18
KRT19
KRT24
KRT25
KRT26
KRT27
KRT3
KRT31
KRT33B
KRT34
KRT35
KRT36
KRT37
KRT38
KRT39
KRT40
KRT6A
KRT75
KRT76
KRT82
KRT86
KRTAP19-5
KRTAP26-1
KRTAP7-1
LASP1
LDOC1
LINC00265
LITAF
LMO1
LMO4
LRRC61
LURAP1
LYST
MAGEB4
MAGED1
MAP3K1
MAP3K10
MAP3K7
MAPK1IP1L
MARK4
MAT2A
MED21
MED22
MED25
MED30
MED4
MED7
MEIS3
MEST
MET
METTL27
MIF4GD
MKNK1
MKRN3
MRFAP1L1
MTHFD1L
NADSYN1
NDC80
NDUFB10
NEDD4
NEDD8
NEFL
NF2
NFYC
NMI
NPAS2
NUP54
NUP62
NUTM2F
ODAD1
ODAM
OIP5
OSBPL5
P4HA3
PAK1
PAX5
PAX6
PEF1
PELP1
PFKM
PIK3R1
PITX1
PKNOX2
PLA2G10
PLAAT1
PLCD1
PLD3
PLEKHB2
PMEPA1
PNMA1
POGZ
POU2AF1
POU6F2
PPP1R16A
PPP1R32
PPP1R7
PPP2R3B
PRR22
PRR5
PSMB11
PSMB4
PTCD3
RASSF4
RBCK1
RFC2
RFX6
RHOBTB3
RINT1
RNF4
RPRD1A
RPS3A
RSPO4
RSU1
RUNX1
SAPCD1
SCAMP3
SCRN1
SCT
SDS
SERGEF
SERTAD3
SF3B3
SMAD2
SMAD3
SMAD5
SMARCB1
SNAP25
SNX1
SNX5
SNX7
SORBS3
SPATA12
SPC25
SPIRE2
SS18L1
STAM
STAM2
STK32C
STMN3
STX11
STXBP1
SUMO1
SUN2
SYK
TADA2A
TASOR2
TBX19
TCP11L2
TEKT1
TEKT5
TFG
TIMM10B
TIMMDC1
TJP2
TLE5
TMCC2
TOM1L1
TP53BP1
TRAF1
TRAF4
TRAK1
TRAP1
TRIM10
TRIM17
TRIM23
TRIM27
TRIM54
TRIM69
TRIM73
TRIML2
TSG101
TUBB
TUBB2A
UBA1
UBA52
UBAP2
UBB
UBC
UBE2I
UBE4B
UBQLN1
UBQLN2
UBQLN4
UBQLNL
UBXN11
USHBP1
USP54
VGLL3
VMP1
VPS37A
VPS37B
VPS37C
VPS37D
VPS52
WASHC1
YPEL3
ZNF302
ZNF34
ZNF430
ZNF44
Entrez ID
7329
9146
HPRD ID
09045
05085
Ensembl ID
ENSG00000103275
ENSG00000185359
Uniprot IDs
A8K503
B0QYN7
P63279
A0A0S2Z4R4
O14964
PDB IDs
1A3S
1KPS
1Z5Q
1Z5S
2GRN
2GRO
2GRP
2GRQ
2GRR
2O25
2PE6
2PX9
2XWU
3A4S
3UIN
3UIO
3UIP
4W5V
4Y1L
5D2M
5F6D
5F6E
5F6U
5F6V
5F6W
5F6X
5F6Y
5FQ2
6SYF
2D3G
3F1I
3OBQ
3ZYQ
4AVX
Enriched GO Terms of Interacting Partners
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