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HSF2BP and NCK2
Data Source:
BioGRID
(two hybrid)
HSF2BP
NCK2
Description
heat shock transcription factor 2 binding protein
NCK adaptor protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome
Cytosol
Cytoplasm
Endoplasmic Reticulum
Cytosol
Vesicle Membrane
Postsynaptic Density
Molecular Function
Protein Binding
Phosphotyrosine Residue Binding
Protein Binding
Cytoskeletal Anchor Activity
Signaling Receptor Complex Adaptor Activity
Signaling Adaptor Activity
Protein-containing Complex Binding
Scaffold Protein Binding
Biological Process
Transcription By RNA Polymerase II
Male Meiosis I
Spermatogenesis
Double-strand Break Repair Involved In Meiotic Recombination
Immunological Synapse Formation
Actin Filament Organization
Signal Transduction
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Cell Population Proliferation
Cell Migration
Lamellipodium Assembly
Positive Regulation Of Actin Filament Polymerization
Negative Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendritic Spine Development
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
Downstream signal transduction
Nephrin family interactions
Ephrin signaling
Activation of RAC1
VEGFA-VEGFR2 Pathway
Regulation of cortical dendrite branching
Drugs
Diseases
GWAS
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Coronary artery disease (
29212778
)
Eosinophil counts (
32888494
)
Eosinophilic esophagitis (
25017104
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Plasma anti-thyroid peroxidase levels (
29678681
)
Pursuit maintenance gain (
29064472
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
Addiction (
23533358
)
Anti-chlamydia trachomatis IgG seropositivity (
33204752
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Systolic blood pressure in sickle cell anemia (
24058526
)
Interacting Genes
293 interacting genes:
ABI2
ABLIM1
ACTN3
ADD1
ANAPC16
ANKRD55
ANKS1B
ARHGAP45
ARHGEF3
ARHGEF4
ARHGEF5
ARHGEF6
ATXN7L2
BARD1
BAX
BAZ2B
BCAS2
BEND7
BEX2
BLK
BMI1
BYSL
C10orf88
C18orf54
C1orf35
C1orf94
C2CD6
C4orf46
C5orf49
C7orf31
C9orf24
CAMSAP3
CARD9
CASS4
CBX8
CBY2
CCDC113
CCDC116
CCDC120
CCDC13
CCDC130
CCDC146
CCDC185
CCDC187
CCDC198
CCDC33
CCHCR1
CCSER1
CDC37
CDC73
CDCA7L
CDR2L
CDYL2
CEP55
CEP57
CKS1B
CLIP4
CNNM1
CNNM3
CNOT2
COIL
CTSZ
CTTNBP2
CTTNBP2NL
CWF19L2
DALRD3
DCDC2B
DEFB112
DMAP1
DMRT3
DOCK8
DPF2
DUSP13
EAF1
EIF3D
ELOA2
EMD
ENKD1
EPHB3
EPM2AIP1
FAM107A
FAM110A
FAM110B
FAM124B
FAM161B
FAM214B
FAM228A
FAM90A1
FBXO44
FHL2
FHL3
FLYWCH1
FUT9
GAS2L2
GAS8
GCM2
GEM
GGN
GNL3L
GOLGA1
GPANK1
GPATCH2L
GPBP1
GPKOW
GPSM3
H2AW
HASPIN
HCK
HDAC4
HEXIM2
HEY2
HNRNPH2
HOMEZ
HOXB5
HOXC8
HSF2
IER2
IL16
INO80B
INPP5J
INSYN2A
IPMK
IQCC
ITGB3BP
JRK
KANK2
KAT5
KIAA0408
KIF24
KIF5B
KIF9
KIFC3
KLF4
L3MBTL2
L3MBTL3
L3MBTL4
LAGE3
LEP
LGALS4
LMO4
LNX1
LRRC29
LRRC56
LRRN4
LUZP4
MAGED1
MAGOHB
MARCHF7
MEF2A
MFAP1
MISP
MKRN3
MVB12A
MYOZ3
NAB2
NCK2
NFIL3
NHSL2
NME4
NPPA
NSMF
NTAQ1
NUDT10
NXF1
ODF3B
ODF3L2
OPTN
P2RX7
PAK6
PAPSS2
PARD6B
PDLIM7
PICK1
PKD2
PKN1
PKP1
PLB1
PLEKHA2
PLEKHA7
PNMA5
POGZ
POLDIP3
POMC
PPM1K
PPP1R18
PPP1R32
PRPF18
PRPF3
PRPF31
PRR5L
PSMA1
PSTPIP1
RAB11FIP2
RAB36
RAB3IL1
RAD51D
RALY
RBM17
RBM41
RBM48
RCOR3
REXO4
RIBC1
RIN1
RNF135
RNF169
ROBO3
RPS28
RTP5
SAMD4A
SAPCD1
SART1
SAXO1
SCNM1
SDCBP
SELENOV
SEMA3B
SEMA4C
SEPTIN1
SEPTIN9
SETDB1
SH2D4A
SHFL
SHISA6
SIRPA
SLAIN1
SLC6A1
SMARCB1
SMARCD1
SMG9
SNAPC1
SNW1
SNX18
SNX21
SPATA22
SPEG
SPG7
SPRED1
SPRY1
SYCE1L
SYNGAP1
TAB2
TAGAP
TASOR2
TBC1D1
TBC1D30
TCEA2
TCF19
TEPSIN
TFIP11
THAP6
TMEFF2
TMSB4X
TNS4
TOX2
TP53BP2
TRAF5
TRARG1
TSEN15
TSGA10IP
TSHZ3
TTC23
TTC9C
TULP3
UBE2I
UPF2
UPRT
USP20
VEZF1
VHL
VPS72
WASF1
WASHC1
WDR25
ZBTB16
ZBTB42
ZC2HC1C
ZCWPW2
ZFC3H1
ZGPAT
ZNF185
ZNF250
ZNF417
ZNF511
ZNF564
ZNF581
ZNF587
ZNF648
ZNF688
ZNF774
ZNF835
ZNF84
ZNF844
171 interacting genes:
ABI1
ABI2
ABI3
ANKRD55
ANKS1B
ARHGAP32
ATN1
AXIN1
AXL
BCAR1
BCL11A
BTG1
C4orf17
CBARP
CBLB
CCDC120
CCDC33
CD3E
CHN1
CHN2
CIB1
CIPC
CLEC17A
CPSF6
CPSF7
CUEDC1
DDR1
DEFB124
DISC1
DLGAP4
DNM1
DOCK1
DOK1
DRAP1
DTX3
DVL1
EEF1G
EFHC2
EFNB1
EFNB2
EFS
EGFR
EIF3H
ERBB2
ERBB3
ERBB4
FAM124A
FAM47A
FAM53C
FAM83A
FASLG
FBXL19
FCRL2
FGFR1
FOSB
FXR2
FYB1
GAB1
GAREM1
GGN
HNRNPK
HOMEZ
HOXA1
HOXC4
HOXD8
HSF2BP
ILK
INCA1
INTS2
IRS1
KCTD17
KHDRBS1
KIAA0408
KIAA1217
KIT
KLHL24
KLHL35
KPRP
LCP2
LIMS1
LNX1
LRRIQ3
LZTS2
MAGEA6
MASP1
MBD6
MEOX2
MET
MIA3
MNT
MYPOP
NCKIPSD
NELFA
NET1
NFKBID
NHSL2
NPAS2
NPHS1
NR5A1
NTRK2
NUTM2F
ONECUT3
PAK1
PAK2
PBX4
PDGFRB
PHETA1
PIK3AP1
PKD1
PKN2
PRDM6
PRR16
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMD10
PTK2
RASSF7
RBBP8NL
RBM26
REEP4
REL
SCML2
SCX
SF1
SF3A2
SF3B4
SHD
SKAP2
SMARCB1
SNW1
SOCS7
SORBS2
SOS1
SPATA2L
SPATC1L
SPRY2
SRMS
SRPK1
SRPK2
SSH3
SYNGAP1
SYNPO
TCF4
TCP10L
TMEM121
TNR
TRIM27
TRIM41
TRIP6
TXK
UBC
USP32
VARS2
VPS37B
WAS
WASF1
WASL
WBP11
WIPF1
WIPF2
ZBTB12
ZBTB42
ZBTB7B
ZC2HC1A
ZC2HC1B
ZNF341
ZNF526
ZNF688
Entrez ID
11077
8440
HPRD ID
05186
05378
Ensembl ID
ENSG00000160207
ENSG00000071051
Uniprot IDs
O75031
Q6IAT7
A0A0S2Z4M6
E7ERP6
O43639
PDB IDs
1U5S
1WX6
1Z3K
2B86
2CIA
2FRW
2FRY
2JXB
4E6R
Enriched GO Terms of Interacting Partners
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