UBE2G1 and UBA1

Data Source:
BioGRID (enzymatic study, enzymatic study, pull down)

		UBE2G1	UBA1
Description		ubiquitin conjugating enzyme E2 G1	ubiquitin like modifier activating enzyme 1
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Hexatantalum Dodecabromide Quercetin
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Plasma trimethylamine N-oxide levels ( 28439531) Refractive error ( 32231278) Small cell lung carcinoma ( 28604730)
Interacting Genes		19 interacting genes: AMFR APP CBL CUL9 DIO2 FBXL2 HUWE1 ITCH MAP3K1 MARCHF6 PRKN RBCK1 RBX1 RC3H1 SMURF1 SYVN1 UBA1 UBE2E1 UBE3A	51 interacting genes: ABCF1 BUB3 CDC34 CDK1 CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2
Entrez ID		7326	7317
HPRD ID		03340	02440
Ensembl ID		ENSG00000132388	ENSG00000130985
Uniprot IDs		P62253	A0A024R1A3 P22314
PDB IDs		2AWF 6D68	4P22 6DC6
Enriched GO Terms of Interacting Partners?
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