UBA1 and HSPH1

Data Source:
HPRD (in vitro)

		UBA1	HSPH1
Description		ubiquitin like modifier activating enzyme 1	heat shock protein family H (Hsp110) member 1
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Protein-containing Complex Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Alpha-tubulin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation	Receptor-mediated Endocytosis Response To Unfolded Protein Positive Regulation Of MHC Class I Biosynthetic Process Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of NK T Cell Activation Regulation Of Cellular Response To Heat
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Scavenging by Class F Receptors Scavenging by Class F Receptors Regulation of HSF1-mediated heat shock response
Drugs		Hexatantalum Dodecabromide Quercetin	Phenethyl Isothiocyanate
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Metabolite levels ( 23823483)
Interacting Genes		51 interacting genes: ABCF1 BUB3 CDC34 CDK1 CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2	16 interacting genes: ADD1 CFL1 CHD3 CSNK2A1 CSNK2A2 DYNLRB1 HSPA8 NMI PAFAH1B1 PAFAH1B3 PGK1 PTEN STK39 TUBA4A UBA1 VAV2
Entrez ID		7317	10808
HPRD ID		02440	09990
Ensembl ID		ENSG00000130985	ENSG00000120694
Uniprot IDs		A0A024R1A3 P22314	A0A024RDQ0 A0A024RDS1 A0A0A0MSM0 B4DY72 Q92598
PDB IDs		4P22 6DC6	6GFA
Enriched GO Terms of Interacting Partners?
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