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UBA1 and BUB3
Data Source:
BioGRID
(two hybrid)
UBA1
BUB3
Description
ubiquitin like modifier activating enzyme 1
BUB3 mitotic checkpoint protein
Image
No pdb structure
GO Annotations
Cellular Component
Heterochromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Lysosomal Membrane
Cytosol
Endosome Membrane
Desmosome
Rough Endoplasmic Reticulum Membrane
Extracellular Exosome
Kinetochore
Condensed Chromosome Kinetochore
Nucleoplasm
Cytosol
Mitotic Checkpoint Complex
Bub1-bub3 Complex
Molecular Function
RNA Binding
Ubiquitin Activating Enzyme Activity
Protein Binding
ATP Binding
Protein Binding
Ubiquitin Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Protein Ubiquitination
Protein Phosphopantetheinylation
Protein Modification By Small Protein Conjugation
Mitotic Sister Chromatid Segregation
Ubiquitin-dependent Protein Catabolic Process
Mitotic Spindle Assembly Checkpoint
Attachment Of Spindle Microtubules To Kinetochore
Anaphase-promoting Complex-dependent Catabolic Process
Protein Localization To Kinetochore
Cell Division
Meiotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Drugs
Hexatantalum Dodecabromide
Quercetin
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Body mass index (
28892062
)
Left-handedness (
32989287
)
Menopause (age at onset) (
24045676
)
Right lateral prefrontal cortical growth (
29682794
)
Interacting Genes
51 interacting genes:
ABCF1
BUB3
CDC34
CDK1
CHEK1
ECHS1
GAN
GRB2
HGS
HSPH1
LINC01554
MGMT
MTNR1A
PIAS3
SEMA3F
SMAD5
SUMO2
TAF9
TMCC2
TSSC4
TTC19
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L1
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2Q2
UBE2R2
UBE2S
UBE2T
UBE2U
UBE2W
UBE2Z
UBTD2
17 interacting genes:
BUB1
BUB1B
CPNE1
EXOC3
HDAC1
HDAC2
PARP1
PARP2
PSTPIP1
PTEN
RBBP7
RPL37A
SUGT1
THRA
TOP1
UBA1
WBP4
Entrez ID
7317
9184
HPRD ID
02440
04761
Ensembl ID
ENSG00000130985
ENSG00000154473
Uniprot IDs
A0A024R1A3
P22314
A0A140VJF3
O43684
PDB IDs
4P22
6DC6
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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