UBA1 and UBE2J2

Data Source:
BioGRID (enzymatic study)

		UBA1	UBE2J2
Description		ubiquitin like modifier activating enzyme 1	ubiquitin conjugating enzyme E2 J2
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation	Protein Polyubiquitination Response To Unfolded Protein Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Hexatantalum Dodecabromide Quercetin
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 28067908)
Interacting Genes		51 interacting genes: ABCF1 BUB3 CDC34 CDK1 CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2	21 interacting genes: AQP6 ATP13A2 ELOVL7 FBXO7 HECW1 HERC4 ITCH MDM2 MGRN1 NEDD4L PRKN RBP1 RNF10 TMEM14B TRIM25 TRIM59 UBA1 UBC UBE2G2 WWP2 XIAP
Entrez ID		7317	118424
HPRD ID		02440	15600
Ensembl ID		ENSG00000130985	ENSG00000160087
Uniprot IDs		A0A024R1A3 P22314	A0A024R075 A6NGS0 Q8N2K1
PDB IDs		4P22 6DC6	2F4W
Enriched GO Terms of Interacting Partners?
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