YAP1 and HNRNPU

Data Source:
HPRD (in vivo, in vitro)

		YAP1	HNRNPU
Description		Yes1 associated transcriptional regulator	heterogeneous nuclear ribonucleoprotein U
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GO Annotations	Cellular Component	Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TEAD-YAP Complex	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Nucleoplasm Telomerase Holoenzyme Complex Centrosome Cell Surface Membrane Nuclear Matrix Nuclear Speck Midbody Dendrite Cytoplasm Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule CRD-mediated MRNA Stability Complex Catalytic Step 2 Spliceosome Mitotic Spindle RNA Polymerase II Transcription Regulator Complex Inactive Sex Chromosome Mitotic Spindle Midzone Mitotic Spindle Microtubule Ribonucleoprotein Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Proline-rich Region Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding TFIIH-class Transcription Factor Complex Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA 3'-UTR Binding Actin Binding Protein Binding ATP Binding Poly(A) Binding SnRNA Binding Poly(C) RNA Binding Chromatin DNA Binding Poly(G) Binding Pre-mRNA Binding Identical Protein Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Telomerase RNA Binding RNA Polymerase II C-terminal Domain Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Trophectodermal Cell Differentiation Tissue Homeostasis Heart Process Embryonic Heart Tube Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Hippo Signaling Wound Healing Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Progesterone Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Contact Inhibition Bud Elongation Involved In Lung Branching Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Development Cardiac Muscle Tissue Regeneration Protein-containing Complex Assembly Interleukin-6-mediated Signaling Pathway Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Organization RNA Processing Cell Cycle Regulation Of Mitotic Cell Cycle Dosage Compensation By Inactivation Of X Chromosome Viral Process RNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Circadian Regulation Of Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Cell Division Maintenance Of Protein Location In Nucleus Cardiac Muscle Cell Development CRD-mediated MRNA Stabilization Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Brown Fat Cell Differentiation Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of Mitotic Spindle Assembly Regulation Of Chromatin Organization Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Protein Localization To Spindle Microtubule RNA Localization To Chromatin Cellular Response To Leukemia Inhibitory Factor Adaptive Thermogenesis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation
Pathways		Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Cleft palate ( 27018472) Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549) Migraine ( 27322543) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 22885925 30566500 26416764) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Pulse pressure ( 30224653 30578418) Reticulocyte count ( 32888494) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		33 interacting genes: ABL1 AKT1 ENAH ERBB4 GAS5 HNRNPU KIF5A LINC00839 NFE2 OTUD1 PRRG2 PTCH1 PTEN PTPN21 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 SUMO3 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP73 WBP1 WBP2 YWHAG YWHAQ YWHAZ	38 interacting genes: ACTB BTRC CASP3 CD5 CDKN2A CR2 DUX4 ELL EP300 ERG GRIN1 GRIN2D GTF2H1 HNRNPH3 HSPB1 IL7R KAT2B NDN NDRG1 NEDD4 NR3C1 PIN1 POLR2A POU3F4 PRMT1 PRPF40A PTPN11 RBPMS2 SMN1 SREK1 STAU1 SUMO2 SYK TCERG1 UBE2I WBP4 YAP1 ZNF689
Entrez ID		10413	3192
HPRD ID		09424	04185
Ensembl ID		ENSG00000137693	ENSG00000153187
Uniprot IDs		A0A024R3E4 K0KVU2 P46937 Q86T74	Q00839 Q96BA7
PDB IDs		1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR 4RE1 4REX 5OAQ 5YDX 5YDY 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6HIL 6Q2X	1ZRJ
Enriched GO Terms of Interacting Partners?
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