YAP1 and SMAD1

Data Source:
BioGRID (affinity chromatography technology, pull down, x-ray crystallography)

		YAP1	SMAD1
Description		Yes1 associated transcriptional regulator	SMAD family member 1
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GO Annotations	Cellular Component	Female Germ Cell Nucleus Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TEAD-YAP Complex	Chromatin Nucleus Nuclear Inner Membrane Nucleoplasm Cytoplasm Cytosol Integral Component Of Membrane Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Proline-rich Region Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Protein Kinase Binding Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding Primary MiRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Trophectodermal Cell Differentiation Tissue Homeostasis Heart Process Embryonic Heart Tube Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Hippo Signaling Wound Healing Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Progesterone Receptor Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Proliferation Contact Inhibition Bud Elongation Involved In Lung Branching Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Development Cardiac Muscle Tissue Regeneration Protein-containing Complex Assembly Interleukin-6-mediated Signaling Pathway Cellular Response To Retinoic Acid Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	MAPK Cascade Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Gamete Generation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Embryonic Pattern Specification Positive Regulation Of Gene Expression Protein Deubiquitination Cell Differentiation BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Cardiac Muscle Cell Proliferation Bone Development SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Sprouting Angiogenesis
Pathways		Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development
Drugs
Diseases
GWAS		Cleft palate ( 27018472) Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549) Migraine ( 27322543) Offspring birth weight ( 31043758) Polycystic ovary syndrome ( 22885925 30566500 26416764) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627) Pulse pressure ( 30224653 30578418) Reticulocyte count ( 32888494) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)	HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Panic disorder ( 31712720) Red cell distribution width ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		33 interacting genes: ABL1 AKT1 ENAH ERBB4 GAS5 HNRNPU KIF5A LINC00839 NFE2 OTUD1 PRRG2 PTCH1 PTEN PTPN21 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 SUMO3 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP73 WBP1 WBP2 YWHAG YWHAQ YWHAZ	160 interacting genes: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APC APP AR ARHGEF6 ARL4D AXIN2 BMPR1A BTBD2 BTG2 BUB1 CAMSAP1 CCND1 CDK7 CDK9 CHMP3 CILK1 COL4A1 CTNNA1 DACH1 DLC1 DNMT3L DVL1 ECSIT EIF2AK4 ELP3 EP300 EPN2 ERBB2 ERBIN EWSR1 FBXL12 FBXO30 FBXW7 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 LMNA MAP2K3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MLH1 MLH3 MRTFB MSH2 MUTYH NAT9 NEDD4 NEDD9 NEUROG1 NKX3-2 NOTCH2 NRAS OAZ1 OAZ3 PAK1 PARD3 PDGFRL PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PTPN12 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STK11 STUB1 SUV39H1 TCF20 TET2 TGFBR1 TLR2 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4
Entrez ID		10413	4086
HPRD ID		09424	03356
Ensembl ID		ENSG00000137693	ENSG00000170365
Uniprot IDs		A0A024R3E4 K0KVU2 P46937 Q86T74	Q15797
PDB IDs		1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR 4RE1 4REX 5OAQ 5YDX 5YDY 6G6X 6G8I 6G8J 6G8K 6G8L 6G8P 6G8Q 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6HIL 6Q2X	1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1 3Q47 3Q4A 5ZOK
Enriched GO Terms of Interacting Partners?
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