HMGB1 and SPINT1

Data Source:
BioGRID (two hybrid)

		HMGB1	SPINT1
Description		high mobility group box 1	serine peptidase inhibitor, Kunitz type 1
Image
GO Annotations	Cellular Component	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Early Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Cell Surface Transcription Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Neuron Projection Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Four-way Junction DNA Binding Bubble DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Lipopolysaccharide Binding Phosphatidylserine Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Cytokine Activity Integrin Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Calcium-dependent Protein Kinase Regulator Activity Lyase Activity C-X-C Chemokine Binding Protein Kinase Activator Activity Chemoattractant Activity RAGE Receptor Binding DNA Polymerase Binding Repressing Transcription Factor Binding Supercoiled DNA Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Myeloid Dendritic Cell Activation Endothelial Cell Proliferation Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Plasmacytoid Dendritic Cell Activation Macrophage Activation Involved In Immune Response Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Topological Change Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Apoptotic DNA Fragmentation DNA Recombination Chromatin Silencing Regulation Of Transcription By RNA Polymerase II Autophagy Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Autophagy Viral Process Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Lung Development Neuron Projection Development Chromatin Assembly Regulation Of Restriction Endodeoxyribonuclease Activity Activation Of Protein Kinase Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Tumor Necrosis Factor Production Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Endothelial Cell Chemotaxis Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Chemotaxis Positive Regulation Of DNA Ligation Response To Glucocorticoid Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Wound Healing Neutrophil Clearance Cellular Response To Interleukin-7 Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleotide-excision Repair Positive Regulation Of Dendritic Cell Differentiation	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Apoptosis induced DNA fragmentation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation	MET Receptor Activation Signaling by MST1
Drugs		Chloroquine Ethyl pyruvate
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30297969) Urate levels ( 31578528)	Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		96 interacting genes: ACBD3 AGER AGTRAP AR ATOH1 C1QBP C3 CASP3 CCAR1 CCNDBP1 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DNM2 DNMT1 DUX4 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FOXA3 FOXC1 GTF2A1 HES1 HMGA1 HNRNPK HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MECP2 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PTPRZ1 RAD23B RAG1 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 SIX5 SOX18 SPINT1 TAF1 TBP TERF2 TERF2IP TFE3 TGIF1 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBE2I UNC119 ZFP36 ZNF24 ZNF428	23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5
Entrez ID		3146	6692
HPRD ID		01228	05494
Ensembl ID		ENSG00000189403	ENSG00000166145
Uniprot IDs		A0A024RDR0 P09429	O43278
PDB IDs		2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM 6OEM 6OEN 6OEO	1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?
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