TLR6

Description		toll like receptor 6
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Phagocytic Vesicle Membrane Toll-like Receptor 2-Toll-like Receptor 6 Protein Complex Receptor Complex Membrane Raft
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Toll-like Receptor 2 Binding Signaling Receptor Activity Identical Protein Binding Protein Heterodimerization Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating Lipopeptide Binding
	Biological Process	Microglial Cell Activation Cell Activation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Gene Expression Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 6 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Detection Of Diacyl Bacterial Lipopeptide Defense Response To Bacterium Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Bacterial Lipopeptide Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta
Pathways		ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Diabetes in response to antihypertensive drug treatment (treatment strategy interaction) ( 27670767) Helicobacter pylori serologic status ( 23652523) Self-reported allergy ( 23817569)
Novel Interacting Genes		1 novel interacting genes: ZYG11B
Interacting Genes		4 interacting genes: BTK HRAS TLR2 TRAP1
Entrez ID		10333
HPRD ID		05656
Ensembl ID		ENSG00000174130
Uniprot IDs		B2R933 Q9Y2C9
PDB IDs		4OM7
Enriched GO Terms of Interacting Partners?
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