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TK1 and FGB
Data Source:
BioGRID
(two hybrid)
TK1
FGB
Description
thymidine kinase 1
fibrinogen beta chain
Image
GO Annotations
Cellular Component
Cytosol
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Plasma Membrane
Cell Cortex
External Side Of Plasma Membrane
Cell Surface
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Synapse
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Extracellular Vesicle
Molecular Function
Thymidine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Identical Protein Binding
Signaling Receptor Binding
Structural Molecule Activity
Extracellular Matrix Structural Constituent
Protein Binding
Cell Adhesion Molecule Binding
Chaperone Binding
Biological Process
Nucleobase-containing Compound Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Phosphorylation
Pyrimidine Nucleoside Salvage
Thymidine Metabolic Process
Protein Homotetramerization
DNA Biosynthetic Process
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Platelet Degranulation
Cell Adhesion
Cell-matrix Adhesion
Blood Coagulation
Extracellular Matrix Organization
Plasminogen Activation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Cellular Protein-containing Complex Assembly
Fibrinolysis
Induction Of Bacterial Agglutination
Cellular Response To Leptin Stimulus
Innate Immune Response
Positive Regulation Of Vasoconstriction
Positive Regulation Of Exocytosis
Positive Regulation Of Protein Secretion
Protein Polymerization
Response To Calcium Ion
Positive Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Interleukin-1
Blood Coagulation, Fibrin Clot Formation
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
G1/S-Specific Transcription
Pyrimidine salvage
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
MAP2K and MAPK activation
Regulation of TLR by endogenous ligand
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Dithioerythritol
Thymidine 5'-triphosphate
Sucralfate
Alfimeprase
Thrombin
Prothrombin
Human thrombin
Thrombin alfa
Anti-inhibitor coagulant complex
Diseases
Afibrinogenemia; Dysfibrinogenemia
Inherited thrombophilia
GWAS
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Leukocyte telomere length (
32109421
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Chronic obstructive pulmonary disease-related biomarkers (
23144326
)
Fibrinogen (
20031576
20031577
23969696
21757653
)
Fibrinogen levels (
29403010
28107422
26561523
)
Ischemic stroke (
29531354
)
Interacting Genes
162 interacting genes:
A1BG
A2M
AAMP
ABHD4
ACTB
ACTL6B
ACTR1B
ADAMTS10
ADD1
AGAP1
ALAS1
ALB
APLP1
APP
ARFGAP1
ATG16L2
ATP5F1B
ATP6V1A
ATXN3
BAG6
BOLA2
BOLA2B
CARHSP1
CCDC115
CCDC90B
CDC20
CDK1
CDK4
CDKN1A
CENPB
CHGB
CLEC3B
COL11A2
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CRMP1
CSAD
DACT1
DALRD3
DCAF13
DDAH2
DEAF1
DMPK
DOCK7
DRAP1
DUS2
DYNC1I1
DYNC2I1
DYNLT2B
EEF1A1
EIF3G
EIF4A2
EIF6
ERG28
EXT2
EZH2
F13A1
FAF1
FAM20C
FBN3
FGB
FLAD1
FST
GAPDH
GDF9
GDI1
GET3
GLB1
GPCPD1
HADHB
HERC3
HMGXB3
HSPBAP1
IER3IP1
IGHM
IMMT
INPP5K
INTS11
ITSN1
JADE1
JMJD1C
KDM6B
KIF21B
KIF5A
KLHL23
KLHL5
KMT2B
LRIF1
MAGEA4
MAST2
MED31
METTL23
MKI67
MPP1
MPPED1
MRFAP1
MRPL20-AS1
MRPL37
MSH2
NEUROD2
NGFR
NKIRAS2
NMT2
NRBP1
ODC1
PAAF1
PDE4DIP
PJA1
PKM
PLD3
PLXNA3
PPP4C
PROC
PSME1
PTPN4
PTPRK
QARS1
RBBP4
RBM48
REX1BD
RPA1
RPL13
RPS2
RUVBL1
RXRA
SDF4
SEMA5B
SEPTIN6
SETDB1
SEZ6L2
SMC5
SNX1
SP110
SULT1A3
SUMO2
SUMO3
TAF1C
THOC3
TIAM2
TLE1
TMSB4X
TP53
TRIM46
TRMT2A
TSC2
TTC38
TUBA1A
TUBB2A
TUBB3
TYK2
UNC119
UPF2
USP4
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZXDC
16 interacting genes:
AIMP2
ANXA7
APP
CALR
CDKN1A
CSNK2B
FBLN1
FGA
FGG
GRB7
LPA
NID1
PIK3R3
SERPINA5
SMN1
TK1
Entrez ID
7083
2244
HPRD ID
01771
00620
Ensembl ID
ENSG00000167900
ENSG00000171564
Uniprot IDs
A0A384MDV9
K7ES52
P04183
P02675
V9HVY1
PDB IDs
1W4R
1XBT
2ORV
2WVJ
1FZA
1FZB
1FZC
1FZE
1FZF
1FZG
1LT9
1LTJ
1N86
1N8E
1RE3
1RE4
1RF0
1RF1
2A45
2FFD
2H43
2HLO
2HOD
2HPC
2OYH
2OYI
2Q9I
2XNX
2XNY
2Z4E
3BVH
3E1I
3GHG
3H32
3HUS
6ATZ
6BIJ
6BIL
Enriched GO Terms of Interacting Partners
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