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TK1 and RXRA
Data Source:
BioGRID
(two hybrid)
TK1
RXRA
Description
thymidine kinase 1
retinoid X receptor alpha
Image
GO Annotations
Cellular Component
Cytosol
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Thymidine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Identical Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Retinoic Acid Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Nuclear Receptor Binding
Enzyme Binding
Peptide Binding
Identical Protein Binding
Vitamin D Receptor Binding
Sequence-specific DNA Binding
Retinoic Acid-responsive Element Binding
DNA Binding Domain Binding
LBD Domain Binding
Vitamin D Response Element Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Nucleobase-containing Compound Metabolic Process
Deoxyribonucleoside Monophosphate Biosynthetic Process
Phosphorylation
Pyrimidine Nucleoside Salvage
Thymidine Metabolic Process
Protein Homotetramerization
DNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Cholesterol Metabolic Process
Bile Acid And Bile Salt Transport
Modulation By Virus Of Host Process
Regulation Of Lipid Metabolic Process
Cell Differentiation
Response To Retinoic Acid
Peroxisome Proliferator Activated Receptor Signaling Pathway
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Anatomical Structure Development
Pathways
G1/S-Specific Transcription
Pyrimidine salvage
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
PPARA activates gene expression
Carnitine metabolism
Regulation of pyruvate dehydrogenase (PDH) complex
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs
Dithioerythritol
Thymidine 5'-triphosphate
alpha-Linolenic acid
Adapalene
Bexarotene
Rosiglitazone
Acitretin
Alitretinoin
Etodolac
Tretinoin
Etretinate
Bezafibrate
Alfacalcidol
Phthalic Acid
Doconexent
Oleic Acid
Arachidonic Acid
EVT-101
3,20-Pregnanedione
2-chloro-5-nitro-N-phenylbenzamide
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
Tributyltin
Diseases
GWAS
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Leukocyte telomere length (
32109421
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
32888494
27863252
28957414
)
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) (
23648065
)
Blood pressure (
24954895
)
Central corneal thickness (
28171582
22814818
31798171
23493294
29760442
30894546
)
Corneal structure (
23291589
)
Crohn's disease (need for surgery) (
23665963
)
Intelligence (
22449649
)
Intraocular pressure (
29617998
)
Refractive error (
32231278
)
Waist-to-hip ratio adjusted for BMI x sex interaction (
26426971
)
Interacting Genes
162 interacting genes:
A1BG
A2M
AAMP
ABHD4
ACTB
ACTL6B
ACTR1B
ADAMTS10
ADD1
AGAP1
ALAS1
ALB
APLP1
APP
ARFGAP1
ATG16L2
ATP5F1B
ATP6V1A
ATXN3
BAG6
BOLA2
BOLA2B
CARHSP1
CCDC115
CCDC90B
CDC20
CDK1
CDK4
CDKN1A
CENPB
CHGB
CLEC3B
COL11A2
COL4A2
COL4A5
COPS6
CPNE6
CRIP2
CRMP1
CSAD
DACT1
DALRD3
DCAF13
DDAH2
DEAF1
DMPK
DOCK7
DRAP1
DUS2
DYNC1I1
DYNC2I1
DYNLT2B
EEF1A1
EIF3G
EIF4A2
EIF6
ERG28
EXT2
EZH2
F13A1
FAF1
FAM20C
FBN3
FGB
FLAD1
FST
GAPDH
GDF9
GDI1
GET3
GLB1
GPCPD1
HADHB
HERC3
HMGXB3
HSPBAP1
IER3IP1
IGHM
IMMT
INPP5K
INTS11
ITSN1
JADE1
JMJD1C
KDM6B
KIF21B
KIF5A
KLHL23
KLHL5
KMT2B
LRIF1
MAGEA4
MAST2
MED31
METTL23
MKI67
MPP1
MPPED1
MRFAP1
MRPL20-AS1
MRPL37
MSH2
NEUROD2
NGFR
NKIRAS2
NMT2
NRBP1
ODC1
PAAF1
PDE4DIP
PJA1
PKM
PLD3
PLXNA3
PPP4C
PROC
PSME1
PTPN4
PTPRK
QARS1
RBBP4
RBM48
REX1BD
RPA1
RPL13
RPS2
RUVBL1
RXRA
SDF4
SEMA5B
SEPTIN6
SETDB1
SEZ6L2
SMC5
SNX1
SP110
SULT1A3
SUMO2
SUMO3
TAF1C
THOC3
TIAM2
TLE1
TMSB4X
TP53
TRIM46
TRMT2A
TSC2
TTC38
TUBA1A
TUBB2A
TUBB3
TYK2
UNC119
UPF2
USP4
WDR18
WDR73
WIZ
ZBTB16
ZNF431
ZXDC
118 interacting genes:
ACVR1
ACVR1B
ALOX15B
ARID5A
ARNTL
BCL3
BRD8
CASP2
CHD9
CLOCK
CNOT1
COPS2
CSNK2B
CTCF
CTNNB1
CTSL
DNMT3L
DNTTIP2
EDF1
ESR1
ESRRA
FUS
GADD45A
GADD45G
GATA2
GK
GRIP1
GSK3B
HDAC3
HDAC4
HMGA1
IGFBP3
ITGB3BP
JAZF1
JMJD1C
KIF1A
KLF5
MAPK1
MAPK3
MAPK7
MECR
MED1
MED24
MED25
MPG
MYOD1
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NFKB1
NFKBIB
NPAS2
NR0B2
NR1H2
NR1H3
NR1H4
NR1I2
NR1I3
NR2E3
NR2F1
NR2F6
NR3C2
NR4A1
NR4A2
NRBF2
NRIP1
NSD1
PARP1
PLK1
PML
POU2F1
POU2F2
PPARA
PPARD
PPARG
PPARGC1A
PRKD2
PRMT2
PSMC3IP
PSMC5
RAD54L2
RARA
RARB
RARG
RELA
RNF8
ROBO4
RPS6KA6
SMAD2
SMARCB1
SMARCD3
SMN1
SNW1
SP1
SRC
SRF
STAT1
TADA3
TAF11
TAF1B
TBP
TDG
THRA
THRB
TK1
TMPRSS3
TRIM24
TRIP10
TRIP4
UBE2I
UBQLN4
VDR
ZBTB16
ZNHIT3
Entrez ID
7083
6256
HPRD ID
01771
01577
Ensembl ID
ENSG00000167900
ENSG00000186350
Uniprot IDs
A0A384MDV9
K7ES52
P04183
A0A5F9ZHH6
F1D8Q5
P19793
Q6P3U7
PDB IDs
1W4R
1XBT
2ORV
2WVJ
1BY4
1DSZ
1FBY
1FM6
1FM9
1G1U
1G5Y
1K74
1MV9
1MVC
1MZN
1R0N
1RDT
1RXR
1XLS
1XV9
1XVP
1YNW
2ACL
2NLL
2P1T
2P1U
2P1V
2ZXZ
2ZY0
3DZU
3DZY
3E00
3E94
3FAL
3FC6
3FUG
3H0A
3KWY
3NSP
3NSQ
3OAP
3OZJ
3PCU
3R29
3R2A
3R5M
3UVV
4CN2
4CN3
4CN5
4CN7
4J5W
4J5X
4K4J
4K6I
4M8E
4M8H
4N5G
4N8R
4NQA
4OC7
4POH
4POJ
4PP3
4PP5
4RFW
4RMC
4RMD
4RME
4ZO1
4ZSH
5EC9
5JI0
5LYQ
5MJ5
5MK4
5MKJ
5MKU
5MMW
5TBP
5UAN
5Z12
5ZQU
6A5Y
6A5Z
6A60
6FBQ
6FBR
6HN6
6JNO
6JNR
6L6K
6SJM
6STI
6XWG
6XWH
7A77
Enriched GO Terms of Interacting Partners
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