FGB and FBLN1

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		FGB	FBLN1
Description		fibrinogen beta chain	fibulin 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Extracellular Vesicle	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Cell Adhesion Molecule Binding Chaperone Binding	Fibronectin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein C-terminus Binding Peptidase Activator Activity Identical Protein Binding Protein-containing Complex Binding Fibrinogen Binding
	Biological Process	Toll-like Receptor Signaling Pathway Adaptive Immune Response Platelet Degranulation Cell Adhesion Cell-matrix Adhesion Blood Coagulation Extracellular Matrix Organization Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein-containing Complex Assembly Fibrinolysis Induction Of Bacterial Agglutination Cellular Response To Leptin Stimulus Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Interleukin-1 Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization Negative Regulation Of ERK1 And ERK2 Cascade Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Motility Negative Regulation Of Stem Cell Proliferation
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Sucralfate Alfimeprase Thrombin Prothrombin Human thrombin Thrombin alfa Anti-inhibitor coagulant complex
Diseases		Afibrinogenemia; Dysfibrinogenemia Inherited thrombophilia	Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
GWAS		Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Fibrinogen ( 20031576 20031577 23969696 21757653) Fibrinogen levels ( 29403010 28107422 26561523) Ischemic stroke ( 29531354)	Blood protein levels ( 30072576) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Low density lipoprotein cholesterol levels ( 32154731) Paneth cell defects in Crohn's disease ( 28352666) QT interval ( 29213071) Red blood cell count ( 27863252) Temperament (bipolar disorder) ( 22365631)
Interacting Genes		16 interacting genes: AIMP2 ANXA7 APP CALR CDKN1A CSNK2B FBLN1 FGA FGG GRB7 LPA NID1 PIK3R3 SERPINA5 SMN1 TK1	62 interacting genes: ACAN ADAMTSL2 ADAMTSL4 AK3 ALG10 APOA1 APP ATN1 BHLHE40 CACNA1A CCN2 CCN3 CHIC2 CREB5 CXCL5 DDIAS ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HOXA1 HSPG2 ITGB1 KRTAP11-1 KRTAP19-2 LCE1A LCE1B LCE1C LCE1F LCE3A LCE5A LINGO1 LMNTD2 LTBP4 MCPH1 MEOX2 MFAP5 MOB4 MRPL12 NEDD1 NID1 NLGN3 NOTCH3 PAX5 PLSCR1 PPARA SKIL SLC66A2 SMAD3 SMAD4 SPRY1 TAF9 TANK TCF7L2 TDGF1 TRIM42 UNKL VCAN YWHAQ
Entrez ID		2244	2192
HPRD ID		00620	00629
Ensembl ID		ENSG00000171564	ENSG00000077942
Uniprot IDs		P02675 V9HVY1	P23142 Q8NBH6
PDB IDs		1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3BVH 3E1I 3GHG 3H32 3HUS 6ATZ 6BIJ 6BIL
Enriched GO Terms of Interacting Partners?
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