TK1 and F13A1

Data Source:
BioGRID (two hybrid)

		TK1	F13A1
Description		thymidine kinase 1	coagulation factor XIII A chain
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GO Annotations	Cellular Component	Cytosol	Extracellular Region Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Blood Microparticle
	Molecular Function	Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Metal Ion Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Phosphorylation Pyrimidine Nucleoside Salvage Thymidine Metabolic Process Protein Homotetramerization DNA Biosynthetic Process	Platelet Degranulation Blood Coagulation Peptide Cross-linking Protein Phosphopantetheinylation Cytokine-mediated Signaling Pathway Blood Coagulation, Fibrin Clot Formation
Pathways		G1/S-Specific Transcription Pyrimidine salvage	Platelet degranulation Common Pathway of Fibrin Clot Formation Interleukin-4 and Interleukin-13 signaling
Drugs		Dithioerythritol Thymidine 5'-triphosphate	N-Acetyl-Serine Thrombin Prothrombin Human thrombin Anti-inhibitor coagulant complex
Diseases			Factor XIII deficiency
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Leukocyte telomere length ( 32109421) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) End-stage coagulation ( 23381943) Entorhinal cortical volume ( 21116278) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Interleukin-10 levels ( 22205395) Night sleep phenotypes ( 27126917) Response to lamotrigine and valproic acid in genetic generalized epilepsy ( 32308125) Type 2 diabetes (age of onset) ( 28060188) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		162 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 BOLA2 BOLA2B CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 DYNC2I1 DYNLT2B EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO2 SUMO3 TAF1C THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZXDC	13 interacting genes: ANXA7 CDKN1A F13B F2 FGA FGG FN1 NUDT21 PTK2 SERPINF2 SH3GL2 TK1 UFD1
Entrez ID		7083	2162
HPRD ID		01771	00604
Ensembl ID		ENSG00000167900	ENSG00000124491
Uniprot IDs		A0A384MDV9 K7ES52 P04183	P00488
PDB IDs		1W4R 1XBT 2ORV 2WVJ	1EVU 1EX0 1F13 1FIE 1GGT 1GGU 1GGY 1QRK 4KTY 5MHL 5MHM 5MHN 5MHO
Enriched GO Terms of Interacting Partners?
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